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Partnership for productive development of biosimilar products: perspectives of ...
Scheinberg,Morton Aaron; Felix,Paulo Antonio Oldani; Kos,Igor Age; Andrade,Maurício De Angelo; Azevedo,Valderilio FeijóABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there ar...
Guillain-Barré syndrome in a patient on adalimumab for the treatment of psoriasis
Natividade,Natallia Barreiros de; Felix,Paulo Antonio Oldani; Lerer,ClaudioAbstract The use of TNF-α inhibitors for the treatment of moderate to severe psoriasis and psoriatic arthritis is increasingly more frequent. The authors report a case of Guillain-Barré syndrome as a late manifestation of the treatment with adalimumab. Although unusual, this is relevant for professionals who prescribe biologic drugs. We also stress the importance of investigating the past and family medical his...