Objective: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. Methods: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility crite...
Ga2O3 bulk single crystals have been implanted with 300 keV Europium ions to fluences ranging from 1x10(13) to 4x10(15) at/cm(2). The damage build-up and Eu-incorporation was assessed by Rutherford Backscattering Spectrometry in the channeling mode (RBS/C). RBS/C results suggest that implantation causes a mixture of defect clusters and extended defects such as dislocations. Amorphisation starts at the surface f...
Superheated droplet detectors (SDDs) have been investigated for applications in neutron dosimetry and spectrometry. Varying the detector temperature, it is possible to change the neutron energy detection threshold of SDDs, thus allowing the use of a single detector to measure neutrons of different energy, without any change of the experimental setup. However, the neutron threshold energy versus temperature curv...
Os autores descrevem um caso de associação de leishmaniose visceral, SIDA e provável tuberculose disseminada. Discutem a possibilidade de associação desta protozoonose e infecção pelo vírus da Imunodeficiência Adquirida (VIH) principalmente pelo aumento de prevalência de infecção pelo VIH em áreas endêmicas para o calazar. A presença de imunodepressão pelo VIH possibilita manifestações de agentes oportunistas m...