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Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched ...
Hachigian, Lea J.; Carmona, Vitor; Fenster, Robert J.; Kulicke, Ruth; Heilbut, Adrian; Sittler, Annie; Almeida, Luís Pereira de; Mesirov, Jill P.Alteration of corticostriatal glutamatergic function is an early pathophysiological change associated with Huntington's disease (HD). The factors that regulate the maintenance of corticostriatal glutamatergic synapses post-developmentally are not well understood. Recently, the striatum-enriched transcription factor Foxp2 was implicated in the development of these synapses. Here, we show that, in mice, overexpre...
Date: 2017
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Origin: Estudo Geral - Universidade de Coimbra