27 documents found, page 1 of 3
The impact of histopathology on prognosis of squamous cell carcinoma of the lar...
Zidar, Nina; Thompson, Lester D. R.; Agaimy, Abbas; Stenman, Göran; Hellquist, Henrik; Nadal, Alfons; Mäkitie, Antti A.; Fernando, LópezDespite decades of progress, laryngeal squamous cell carcinoma (SCC) is still associated with significant morbidity and mortality worldwide. Additional biomarkers are needed to apply precision medicine and predict the clinical course. We reviewed and summarised routinely reported histopathologic features (e.g. subtypes of laryngeal SCC) along with promising potential biomarkers not yet routinely assessed using ...
Metastatic cutaneous squamous cell carcinoma accounts for nearly all squamous c...
Bradley, Patrick J.; Stenman, Göran; Thompson, Lester D. R.; Skálová, Alena; Simpson, Roderick H. W.; Slootweg, Pieter J.; Franchi, AlessandroPrimary squamous cell carcinoma of the parotid gland (pSCCP) has long been recognized as a separate entity and is included in the WHO classifications of salivary gland tumors. However, it is widely accepted among head and neck pathologists that pSCCP is exceptionally rare. Yet, there are many publications describing series of pSCCP and data from SEER and other cancer register databases indicate erroneously an i...
Molecularly defined sinonasal malignancies: an overview with focus on the curre...
Skálová, Alena; Agaimy, Abbas; Bradova, Martina; Poorten, Vincent Vander; Hanna, Ehab; Guntinas-Lichius, Orlando; Franchi, Alessandro; Hellquist, HenrikClassification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of...
Update on olfactory neuroblastoma
Lopez, Fernando; Agaimy, Abbas; Franchi, Alessandro; Suárez, Carlos; Vander Poorten, Vincent; Mäkitie, Antti A.; Homma, Akihiro; Eisbruch, AvrahamOlfactory neuroblastomas are uncommon malignancies that arise from olfactory receptor cells located high in the nasal cavity. Accurate diagnosis plays a crucial role in determining clinical results and guiding treatment decisions. Diagnosis can be a major challenge for pathologists, especially when dealing with tumours with poor differentiation. The discovery of several molecular and immunohistochemical markers...
Massive parallel sequencing of head and neck conventional squamous cell carcino...
Nadal, Alfons; Cardesa, Antonio; Agaimy, Abbas; Almangush, Alhadi; Franchi, Alessandro; Hellquist, Henrik; Leivo, Ilmo; Zidar, Nina; Ferlito, AlfioHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is a cause of signifcant mortality and morbidity. The epidemiology of this cancer varies worldwide due to either genetic diferences in populations or diferences in carcinogen exposure. The application of massive parallel sequencing-based techniques in HNSCC should provide a helpful understanding of the genetic alteration...
Neutrophil to lymphocyte ratio in oropharyngeal squamous cell Carcinoma: A syst...
Rodrigo, Juan P.; Sánchez-Canteli, Mario; Triantafyllou, Asterios; de Bree, Remco; Mäkitie, Antti A.; Franchi, Alessandro; Hellquist, HenrikNeutrophil-to-lymphocyte ratio (NLR) has been associated with survival in various cancers, including head and neck cancer. However, there is limited information on its role in oropharyngeal squamous cell carcinomas (OPSCC) according to HPV status. This prompted the present metaanalysis. Studies were selected when the prognostic value of NLR prior to treatment was evaluated in OPSCC patients, the cutoff value of...
Development of head and neck pathology in Europe
Hellquist, Henrik; Agaimy, Abbas; Stenman, Göran; Franchi, Alessandro; Nadal, Alfons; Skalova, Alena; Leivo, Ilmo; Zidar, Nina; Simpson, Roderick H. W.This review gives a brief history of the development of head and neck pathology in Europe from a humble beginning in the 1930s to the explosive activities the last 15 years. During the decades before the introduction of immunohistochemistry in the 1980s, head and neck pathology grew as a subspeciality in many European countries. In the late 1940s, the Institute of Laryngology and Otology with its own pathology ...
Chromosome translocations, gene fusions, and their molecular consequences in pl...
Stenman, Göran; Fehr, Andre; Skálová, Alena; Vander Poorten, Vincent; Hellquist, Henrik; Mikkelsen, Lauge Hjorth; Saba, Nabil F.Salivary gland tumors are a heterogeneous group of tumors originating from the major and minor salivary glands. The pleomorphic adenoma (PA), which is the most common subtype, is a benign lesion showing a remarkable morphologic diversity and that, upon recurrence or malignant transformation, can cause significant clinical problems. Cytogenetic studies of >500 PAs have revealed a complex and recurrent pattern of...
Clear cell neoplasms of salivary glands: A diagnostic challenge
Skalova, Alena; Leivo, Ilmo; Hellquist, Henrik; Simpson, Roderick H.W.; Vander Poorten, Vincent; Willems, Stefan M.; Mosaieby, Elaheh; Slouka, DavidThis review focuses on the heterogenous group of clear cell neoplasms of salivary glands and attempts to identify major differential diagnostic features. Within the head and neck region, clear cells are found most commonly in salivary gland tumors, but may also be seen in tumors of squamous or odontogenic epithelial origin, primary or metastatic carcinomas, benign or malignant melanocytic lesions, or benign or ...
High-grade transformation/dedifferentiation in salivary gland carcinomas: occur...
Skalova, Alena; Leivo, Ilmo; Hellquist, Henrik; Agaimy, Abbas; Simpson, Roderick H. W.; Stenman, Goran; Vander Poorten, Vincent; Bishop, Justin A.High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade comp...