19 documents found, page 1 of 2
In vitro and in vivo assessment of nanoceria biocompatibility for their safe us...
Fernández-Bertólez, N; Martínez, L; Ramos-Pan, L; Touzani, A; Costa, C; Laffon, B; Valdiglesias, VNanoceria, or cerium dioxide nanoparticles (CeO2 NP), are increasingly employed in a number of industrial and commercial applications. Hence, the environmental presence of these nanoparticles is growing progressively, enhancing the global concern on their potential health effects. Recent studies suggest that nanoceria may also have promising biomedical applications particularly in neurodegenerative and brain-re...
Toxicity of zinc oxide nanoparticles: Cellular and behavioural effects
Fernández-Bertólez, N; Alba-González, A; Touzani, A; Ramos-Pan, L; Méndez, J; Reis, AT; Quelle-Regaldie, A; Sánchez, L; Folgueira, M; Laffon, BDue to their extensive use, the release of zinc oxide nanoparticles (ZnO NP) into the environment is increasing and may lead to unintended risk to both human health and ecosystems. Access of ZnO NP to the brain has been demonstrated, so their potential toxicity on the nervous system is a matter of particular concern. Although evaluation of ZnO NP toxicity has been reported in several previous studies, the speci...
Association between cognitive reserve proxies and frailty phenotype: data from ...
Lorenzo-López, L; Cibeira, N; Hemadeh, A; López-López, R; Lema-Arranz, C; Maseda, A; Fernández-Bertólez, N; Costa, S; Pásaro, E; Valdiglesias, VA potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank. We included 31,975 dementia-free participants aged ≥ 60 years (50.7% females, 2.2% frail) who completed a web-based cognitive assessment (fluid intelligence, wor...
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Mohyuddin, H; Laffon, B; Teixeira, JP; Costa, S; Teixeira-Gomes, A; Pásaro, E; Constantine, N; Dagdag, A; Ortmeyer, HK; Tizenberg, B; Afram, L; Yen, PYBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analy...
Impact of gold nanoparticle exposure on genetic material
Ramos-Pan, L; Touzani, A; Fernández-Bertólez, N; Fraga, S; Laffon, B; Valdiglesias, VMetal nanoparticles, with gold nanoparticles (AuNP) at the forefront, have gained immense attention due to their unique properties. At the nanoscale, gold exhibits remarkable physical, chemical, optical, and electronic features, making it ideal for a plethora of applications, including bioimaging, sensing, diagnostics, and drug delivery. Despite their promising utility, concerns have arisen regarding the potent...
Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish ...
Valdiglesias, V; Alba-González, A; Fernández-Bertólez, N; Touzani, A; Ramos-Pan, L; Reis, AT; Moreda-Piñeiro, J; Yáñez, J; Laffon, B; Folgueira, MZinc oxide nanoparticles (ZnO NPs) are among the most widely used nanomaterials. They have multiple applications in cosmetics, textiles, paints, electronics and, recently, also in biomedicine. This extensive use of ZnO NPs notably increases the probability that both humans and wildlife are subjected to undesirable effects. Despite being among the most studied NPs from a toxicological point of view, much remains...
Toxicological Aspects of Iron Oxide Nanoparticles
Fernández-Bertólez, N; Costa, C; Brandão, F; Teixeira, JP; Pásaro, E; Valdiglesias, V; Laffon, BIron oxide nanoparticles (ION), with unique magnetic properties, have attracted huge scientific attention for a wide variety of uses, mostly in the biomedical field, due to their high biocompatibility, ability to cross biological membranes, appropriate surface architecture and easy conjugation with targeting ligands. Their current applications include diagnostic imaging, cell labelling, site-directed drug deliv...
Relationship between DNA damage measured by the comet-assay and cognitive function
Lorenzo-López, L; Lema-Arranz, C; Fernández-Bertólez, N; Costa, S; Costa, C; Teixeira, JP; Pásaro, E; Valdiglesias, V; Laffon, BRecent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and...
Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicit...
Fernández-Bertólez, N; Brandão, F; Costa, C; Pásaro, E; Teixeira, JP; Laffon, B; Valdiglesias, VStandard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) test is recommended for genotoxicity testing, but cytochalasin-B (Cyt-B) may interfere with nanoparticles (NP), leading to inaccurate results. Our objective was to determine whether Cyt-B could interfere ...
Salivary Leucocytes as In Vitro Model to Evaluate Nanoparticle-Induced DNA Damage
Valdiglesias, V; Fernández-Bertólez, N; Lema-Arranz, C; Rodríguez-Fernández, R; Pásaro, E; Reis, AT; Teixeira, JP; Costa, C; Laffon, BMetal oxide nanoparticles (NPs) have a wide variety of applications in many consumer products and biomedical practices. As a result, human exposure to these nanomaterials is highly frequent, becoming an issue of concern to public health. Recently, human salivary leucocytes have been proposed as an adequate non-invasive alternative to peripheral blood leucocytes to evaluate genotoxicity in vitro. The present stu...