4 documents found, page 1 of 1
Altered striatal endocannabinoid signaling in a transgenic mouse model of spino...
Rodríguez-Cueto, Carmen; Hernández-Gálvez, Mariluz; Hillard, Cecília J.; Maciel, P.; Valdeolivas, Sara; Ramos, José A.; Gómez-Ruiz, MariaSpinocerebellar ataxia type-3 (SCA-3) is the most prevalent autosomal dominant inherited ataxia. We recently found that the endocannabinoid system is altered in the post-mortem cerebellum of SCA-3 patients, and similar results were also found in the cerebellar and brainstem nuclei of a SCA-3 transgenic mouse model. Given that the neuropathology of SCA-3 is not restricted to these two brain regions but rather, i...
Dysregulation of the endocannabinoid signaling system in the cerebellum and bra...
Maciel, P.; Rodríguez-Cueto, Carmen; Hernández-Gálvez, Mariluz; Hillard, Cecília J.; García-García, Luís; Valdeolivas, Sara; Pozo, Miguel A.Spinocerebellar ataxia type-3 (SCA-3) is a rare disease but it is the most frequent type within the autosomal dominant inherited ataxias. The disease lacks an effective treatment to alleviate major symptoms and to modify disease progression. Our recent findings that endocannabinoid receptors and enzymes are significantly altered in the post-mortem cerebellum of patients affected by autosomal-dominant hereditary...
Effects of neonatal exposure to methamphetamine: Catecholamine levels in brain ...
Silva, Joana Gomes da; Miguel, Rosário de; Fernández-Ruiz, Javier; Summavielle, Teresa; Tavares, M. Amélia; Summavielle, TeresaNeonatal exposure to moderate doses of methamphetamine during the first month of life in the rat affects tyrosine hydroxylase gene expression in the substantia nigra and nigrostriatal tyrosine hydroxylase activity. The main goal of this work was to evaluate the ontogeny of the neurochemical effects of repeated exposure to moderate doses of methamphetamine during the first month of life in the rat. Norepinephrin...
Transthyretin is involved in depression-like behaviour and exploratory activity
Sousa, João Carlos; Grandela, Catarina; Fernández-Ruiz, Javier; Miguel, Rosário de; Sousa, Liliana de; Magalhães, Ana Isabel; Saraiva, Maria JoãoTransthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the per...