4 documents found, page 1 of 1
Oral Salvia officinalis phenolics abolish mortality and mitigate inflammation i...
Direito, Rosa; Rocha, João; Melo, Inês Alves de; Gonçalves, Margarida; Duarte, Maria Paula; Fernandes, Adelaide; Sepodes, Bruno; Figueira, Maria-EduardoPublisher Copyright: © 2025; Background: This study is the first to evaluate a phenolic extract of Salvia officinalis in the TNBS murine model of colitis. Inflammatory bowel disease (IBD) involves transmural oxidative and nitrosative stress that up-regulates inducible nitric-oxide synthase (iNOS) and cyclo‑oxygenase-2 (COX-2). Although phenolic constituents of S. officinalis are anti-inflammatory in vitro, thei...
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoPublisher Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.; In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB...
Attenuation of colonic injury and inflammation by administration of a phenolic ...
Rocha, João; Leandro, Raquel; Direito, Rosa; Gonçalves, Margarida; Duarte, Maria Paula; Fernandes, Adelaide; Sepodes, Bruno; Figueira, Maria EduardoUIDB/04077/2020; Summer Savory (Satureja hortensis L.) is a plant traditionally used as a food spice in the Mediterranean region. Surprisingly, not much is known about the health beneficial effects of its phenolic-rich extracts. The majority of publications have always focused on the properties of their essential oil. One of the main phenolic compounds of Summer Savory is rosmarinic acid, which has demonstrated...
Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in E...
Direito, Rosa; Rocha, João; Lima, Ana; Gonçalves, Maria Margarida Boavida Pontes; Duarte, Maria Paula Amaro de Castilho; Mateus, VanessaBackground: Inflammatory Bowel Diseases (IBD) encompasses both Crohn’s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). Spearmint (Mentha spicata L.) is a Mediterranean plant used as an aromatic agent, and studies have mainly focused on the essential oil suggesting an anti-inflammatory activity. This work aimed to perform a preliminary screening o...