11 documents found, page 1 of 2
Transcriptomic-Based Classification Identifies Prognostic Subtypes and Therapeu...
Esperança-Martins, Miguel; Vasques, Hugo; Ravasqueira, Manuel Sokolov; Lemos, Maria Manuel; Fonseca, Filipa; Coutinho, Diogo; López, Jorge AntonioFunding Information: This research was sponsored by F.Hoffmann-LaRoche AG and by Foundation Medicine Inc. under the RNA LDT Research Programme. Funding Information: We would like to thank F.Hoffmann-LaRoche AG and Foundation Medicine Inc. for providing the FoundationOneCDx and FoundationOneRNA assays, and for all the technical support, specifically during the transfer of the sequencing data via the safe platfor...
Practical Guidance on the Detection of NTRK Fusions in Sarcomas
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloPublisher Copyright: © 2025 CELOM. All rights reserved.; Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed no...
A Case of Success
Soares de Pinho, Inês; Esperança-Martins, Miguel; Machado, Bárbara; Dâmaso, Sara; Lopes Brás, Raquel; Cantinho, Guilhermina; Fernandes, IsabelRadium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, an...
Transcriptomic Analyses Reveal That Coffea arabica and Coffea canephora Have Mo...
Marques, Isabel; Fernandes, Isabel; Paulo, Octávio S.; Batista, Dora; Lidon, Fernando C.; Rodrigues, Ana P.; Partelli, Fábio L.; DaMatta, Fábio M.Funding Information: Fellowships from the Conselho Nacional de Desenvolvimento Cient\u00EDfico e Tecnol\u00F3gico, Brazil (CNPq) (FLP, FMD), and the Funda\u00E7\u00E3o de Amparo \u00E0 Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG, project CRA-RED-00053-16, APQ01512-18) (FMD), are also greatly acknowledged. Publisher Copyright: © 2024 by the authors.; Increasing exposure to unfavorable temperatures and wa...
Overexpression of Water-Responsive Genes Promoted by Elevated CO2 Reduces ROS a...
Marques, Isabel; Fernandes, Isabel; Paulo, Octávio S.; Batista, Dora; Lidon, Fernando C.; Partelli, Fábio; DaMatta, Fábio M.; Ribeiro-Barros, Ana I.Project UID/AGR/04129/2020 (LEAF). Fellowships from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil (CNPq) for F.L.P. and F.M.D. and the Fundação de Amparo á Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG, project CRA-RED-00053-16; APQ01512-18, to F.M.D.) are also greatly acknowledged. Publisher Copyright: © 2023 by the authors.; Drought is a major constraint to plant growth and p...
Salt Stress Tolerance in Casuarina glauca
Fernandes, Isabel; Paulo, Octávio S.; Marques, Isabel; Sarjkar, Indrani; Sen, Arnab; Graça, Inês; Pawlowski, Katharina; Ramalho, José C.Publisher Copyright: © 2022 by the authors.; Climate change and the accelerated rate of population growth are imposing a progressive degradation of natural ecosystems worldwide. In this context, the use of pioneer trees represents a powerful approach to reverse the situation. Among others, N2-fixing actinorhizal trees constitute important elements of plant communities and have been successfully used in land rec...
International consensus on antinuclear antibody em Portugal
Sousa, Maria José; Neves, Esmeralda; Figueiras, Otília; Cruz, Ana Paula; Fernandes, Isabel; Mendes, Alexandra; Santos, Maria do Céu; Cunha, RosárioIntroduction: Screening for autoantibodies in HEp-2 cells by indirect immunofluorescence is currently accepted as the gold-standard test for the diagnosis of systemic autoimmune diseases. The main objective of the International Consensus on ANA Patterns is to achieve a consensus on the nomenclature and description of antinuclear antibody morphological patterns. This work aims to build on the International Conse...
A transcriptomic approach to understanding the combined impacts of supra‐optima...
Marques, Isabel; Fernandes, Isabel; Paulo, Octávio S.; Lidon, Fernando C.; Damatta, Fábio M.; Ramalho, José C.; Ribeiro‐Barros, Ana I.Fellowships from the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq), and the Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG, project CRA‐RED−00053–16), to F.M.DM., are also greatly acknowledged.; Understanding the effect of extreme temperatures and elevated air (CO2) is crucial for mitigating the impacts of the coffee industry. In this work, leaf transcrip...
Understanding the impact of drought in coffea genotypes
Fernandes, Isabel; Marques, Isabel; Paulo, Octávio S.; Batista, Dora; Partelli, Fábio L.; Lidon, Fernando C.; Damatta, Fábio M.; Ramalho, José C.Fellowships from CNPq, Brazil (F.L. Partelli and F.M. DaMatta), and FAPEMIG, Brazil (project CRA-RED-00053-16, to F.M. DaMatta) are also greatly acknowledged. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.; Water scarcity is the most significant factor limiting coffee production, although some cultivars can still have important drought tolerance. This study analyzed leaf transcri...
Transcriptomic leaf profiling reveals differential responses of the two most tr...
Marques, Isabel; Fernandes, Isabel; David, Pedro H. C.; Paulo, Octávio S.; Goulão, Luis F.; Fortunato, Ana S.; Lidon, Fernando C.; Damatta, Fábio M.PTDC/ASP-AGR/31257/2017 UIDB/00239/2020 UIDP/04035/2020 UID/AGR/04129/2020 UIDB/04551/2020 CRA-RED-00053-16; As atmospheric [CO2] continues to rise to unprecedented levels, understanding its impact on plants is imperative to improve crop performance and sustainability under future climate conditions. In this context, transcriptional changes promoted by elevated CO2 (eCO2) were studied in genotypes from the two ...