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Hybrid next-generation sequencing protocol for testing HIV-2 drug resistance

Gonçalves, Fátima; Cabanas, Joaquim; Costa, Inês; Veloso, Margarida; Ribeiro, Marta; Fernandes, Sandra; Diogo, Isabel; Sebastião, Cruz S.

Funding Information: Researchers from GHTM|IHMT, CNIC, CISA, or INIS received financial support from FCT-Foundation for Science and Technology (MARVEL project - PTDC/SAU-PUB/4018/2021), FCG-Calouste Gulbenkian Foundation (HITOLA project - N\u00BA.250466), PDCT-Science and Technology Development Project (N\u00BA.36 MESCTI/PDCT/2022), GHTM-UID/04413/2020 and LA-REAL-LA/P/0117/2020. Egas Moniz Center for Interdisc...


The logic of distinction

Meyer Resende, Madalena; Rocha, Bruno; Fernandes, Sandra

UIDB/04627/2020 UIDP/04627/2020; This article proposes a framework that captures the logic of status seeking and reassesses the influence of one of its key drivers: nationalism. Inspired by Bourdieu’s logic of distinction, the article conceptualises status as a form of social distinction and argues that nationalism influences status seeking based on variations in its external dimension. By examining the case of...


Applying Next-Generation Sequencing to Track HIV-1 Drug Resistance Mutations Ci...

Pimentel, Victor; Pingarilho, Marta; Sebastião, Cruz S.; Miranda, Mafalda; Gonçalves, Fátima; Cabanas, Joaquim; Costa, Inês; Diogo, Isabel

Funding Information: This research was funded by FCT in the Scopus of INTEGRIV project (PTDC/SAU-INF/31990/2017), FCT MARVEL (PTDC/SAU-PUB/4018/2021), Calouste Gulbenkian Foundation (FCG), under the ENVOLVE Ci\u00EAncia PALOP program that funded the HITOLA project (N\u00BA.250466), Africa Research Excellence Fund (AREF) (AREF-312-CRUZ-F-C0931), Science and Technology Development Project (PDCT) within the scope ...


Determinants of HIV late presentation among men who have sex with men in Portug...

Abrantes, Ricardo; Pimentel, Victor; Miranda, Mafalda N. S.; Silva, Ana Rita; Diniz, António; Ascenção, Bianca; Piñeiro, Carmela; Koch, Carmo

Funding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the European funds through grant Bio-Molecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Co-Infections and Ongoing Transmission Patterns in Europe (BEST HOPE) (project funded through HIVERA: Harmonizing Integr...


Differential patterns of post-migration HIV-1 infection acquisition among Portu...

Pimentel, Victor Figueiredo; Pingarilho, Marta; Sole, Giordano; Alves, Daniela; Miranda, Mafalda; Diogo, Isabel; Fernandes, Sandra; Pineda-pena, Andrea

OBJECTIVE: To investigate the dynamics of phylogenetic transmission clusters involving immigrants of Portuguese Speaking Countries living in Portugal. DESIGN/METHODS: We included genomic sequences, sociodemographic and clinical data from 772 HIV migrants followed in Portugal between 2001 and 2017. To reconstruct HIV-1 transmission clusters, we applied phylogenetic inference from 16 454 patients: 772 migrants, 2...


Increasing prevalence of HIV-1 transmitted drug resistance in Portugal

Pingarilho, Marta; Pimentel, Victor; Diogo, Isabel; Fernandes, Sandra; Miranda, Mafalda; Pineda-Peña, AC; Libin, Pieter; Theys, Kristof; Martins, MR

Introduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug resistance (ADR). Objective: To study the trends of TDR and ADR in patients followed up in Portuguese hospitals between 2001 and 2017. Methods: In total, 11,911 p...


Molecular epidemiology of HIV-1 infected migrants followed up in Portugal

Pimentel, Victor; Pingarilho, Marta; Alves, Daniela; Diogo, Isabel; Fernandes, Sandra; Miranda, Mafalda; Pineda-Peña, Andrea Clemencia; Libin, Pieter

Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as ...


Trinta Anos do Fim do Comunismo

Fernandes, Sandra; Meyer Resende, Madalena

UID/CPO/04627/2019


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