6 documents found, page 1 of 1

Serum amyloid A proteins reduce bone mass during mycobacterial infections

IntroductionOsteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. MethodsGenetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healt...

Disfunção Plaquetária Induzida pelo Darunavir em Doente com Infeção VIH-1

As plaquetas desempenham um papel importante na hemóstase primária e a sua disfunção pode resultar em manifestações hemorrágicas, principalmente, mucocutâneas. Apesar das manifestações serem, na maioria das vezes, de gravidade ligeira a moderada, os doentes com disfunção plaquetária podem constituir um desafio hemostático, quando submetidos a procedimentos invasivos. As causas podem ser hereditárias ou adquirid...

INR vs Doseamento de Fator X Cromogénico e Fator II: C em Doentes com Síndrome ...

Os fatores dependentes da vitamina K podem estar diminuídos de modo variável, sendo o Fator (F) II e o FX os principais determinantes relativamente ao efeito antitrombótico. A ligação dos anticorpos antifosfolipídicos aos fosfolípidos pode causar um falso prolongamento do tempo de protrombina (TP) em doentes com anticoagulante lúpico. Correlacionámos os resultados da razão normalizada internacional (INR) – usan...

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...

Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...

Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...

A Critical Analysis of Our Experience As Participants in an External Quality As...