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The application of Bonelike® Poro as a synthetic bone substitute for the manage...

Pinto, PO; Branquinho, MV; Caseiro, AR; Sousa, AC; Brandão, A; Pedrosa, SS; Alvites, RD; Campos, JM; Santos, FL; Santos, JD; Mendonça, CM; Amorim, I

The effective treatment of non-unions and critical-sized defects remains a challenge in the orthopedic field. From a tissue engineering perspective, this issue can be addressed through the application bioactive matrixes to support bone regeneration, such as Bonelike®, as opposed to the widespread autologous grafting technique. An improved formulation of Bonelike® Poro, was assessed as a synthetic bone substitut...


Rat Olfactory Mucosa Mesenchymal Stem/Stromal Cells (OM-MSCs): A Characterizati...

Alvites, RD; Branquinho, MV; Caseiro, AR; Amorim, I; Santos Pedrosa, S; Rêma, A; Faria, F; Porto, B; Oliveira, C; Teixeira, P; Magalhães, R; Geuna, S

Stem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair of damaged or dysfunctional tissues and organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded as a promising tool in regenerative therapies because of their several favorable properties such as multipotency, high proliferation rate, helpful location, and few associ...


Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: A c...

Caseiro, AR; Pedrosa, SS; Ivanova, G; Branquinho, MV; Almeida, A; Faria, F; Amorim, I; Pereira, T; Maurício, AC

Mesenchymal Stem/ Stromal Cells assume a supporting role to the intrinsic mechanisms of tissue regeneration, a feature mostly assigned to the contents of their secretome. A comparative study on the metabolomic and bioactive molecules/factors content of the secretome of Mesenchymal Stem/ Stromal Cells derived from two expanding sources: the umbilical cord stroma and the dental pulp is presented and discussed. Th...


Neuro-muscular Regeneration using scaffolds with Mesenchymal stem cells (MSCS) ...

Caseiro, AR; Pereira, T; Ribeiro, J; Santos, JD; Irina Amorim; luis, al; Mauricio, AC


Mesenchymal Stem cells and Biomaterials Systems - Perspectives for Skeleton Mus...

Caseiro, AR; Pereira, T; Bártolo, PJ; Santos, JD; Luís, AL; Mauricio, AC


Mesenchymal Stem Cells and Biomaterials Systems - Perspectives for Skeletal Mus...

Caseiro, AR; Pereira, T; Bártolo, PJ; Santos, JD; Luís, AL; Maurício, AC

Skeletal muscle is essential in voluntary movement and other major vital functions. Muscle injuries are important in clinical practice and, despite skeletal muscle's good regenerative ability, severe tissue loss impairs complete myofibre regeneration, limiting structural and functional recovery of the affected muscle, eventually leading to the development of non-contractile fibrous scar. The intrinsic healing m...


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