13 documents found, page 1 of 2
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cati...
Fernandes, Ana R.; Santos, Tiago dos; Granja, Pedro L.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B.Age-related macular degeneration (AMD) is defined as a degenerative, progressive and multifactorial disorder that affects the macula with a complex etiology. The retinal pigment epithelium is a monolayer of cells that has the function to separate the surface of the choroid from the neural retina that is involved in the signal transduction leading to vision. The blood-aqueous barrier and the blood retinal barrie...
Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading ...
Fernandes, Ana R.; Sanchez-Lopez, Elena; Santini, Antonello; Santos, Tiago dos; Garcia, Maria L.; Silva, Amélia Maria Lopes Dias da; Souto, Eliana B.Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, ...
Mono- and dicationic DABCO/Quinuclidine composed nanomaterials for the loading ...
Fernandes, Ana R.; Sanchez-Lopez, Elena; Santini, Antonello; Santos, Tiago dos; Garcia, Maria L.; Silva, Amélia M.; Souto, Eliana B.Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, ...
Polymer nanogels: Fabrication, structural behavior, and biological applications
Pashirova, Tatiana N.; Fernandes, Ana R.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Zakharova, Lucia Ya.; Souto, Eliana B.Nanogels are defined as colloids-based hydrogels, representing a three-dimensional network of a hydrophilic polymer in which drugs can be entrapped. Nanogels are soft, conformable, highly permeable, and stimuli-responsive networks, which can be surface-modified with functional groups aiming at conjugation with small and large macromolecules. Nanogels also offer several advantages attributed to their capacity to...
Chapter 13 - Skin rejuvenation: Biopolymers applied to UV sunscreens and sheet ...
Dias-Ferreira, João; Fernandes, Ana R.; Soriano, José L.; Naveros, Beatriz C.; Severino, Patricia; da Silva, Classius Ferreira; Souto, Eliana B.As the largest organ of the body and the most exposed to the environmental surroundings, the skin has increased risk of suffering injuries from harmful substances, which may compromise its degree of hydration, elasticity, and integrity. Among the most relevant elements that can injure the skin, ultraviolet (UV) radiations are responsible for the generation of reactive oxygen species that may undergo intracellul...
Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial ...
Campos, Joana R.; Fernandes, Ana R.; Sousa, Raquel; Fangueiro, Joana F.; Boonme, Prapaporn; Garcia, Maria Luisa; Silva, Amelia M.; Naveros, Beatriz C.The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10wt% of glyceryl behenate and 2.5wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SLN was 166.1±0.114nm, with a polydispersity index (PI) of 0.171±0051 and zeta potential nearly neu...
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-su...
Pashirova, Tatiana N.; Burilova, Evgeniya A.; Lukashenko, Svetlana S.; Gaysin, Nail K.; Gnezdilov, Oleg I.; Sapunova, Anastasia S.; Fernandes, Ana R.Self-assembly and solubilization properties of amphiphilic mono- and bisquaternized derivatives of 1,4-diazabicyclo[2.2.2]octane (mono-CS-n and di-CS-n, where CS cationic surfactant, n=12, 14, 16, 18) was investigated by nuclear magnetic resonance with magnetic field pulse gradient. The influence of Dabco-surfactant structure (head group and length of alkyl chains) on critical micelle concentration and aggregat...