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Myeloid Sirtuin 2 expression does not impact long-term Mycobacterium tuberculos...

Cardoso, Filipa; Castro, Flávia Raquel Teixeira de; Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; Torrado, Egídio

Sirtuins (Sirts) regulate several cellular mechanisms through deacetylation of several transcription factors and enzymes. Recently, Sirt2 was shown to prevent the development of inflammatory processes and its expression favors acute Listeria monocytogenes infection. The impact of this molecule in the context of chronic infections remains unknown. We found that specific Sirt2 deletion in the myeloid lineage tran...


Impact of IL-10 and SIRT2 in the protective immune response to Mycobacterium tu...

Castro, Flávia Raquel Teixeira de

Dissertação de mestrado em Ciências da Saúde; The host immune system needs to respond to the pathogens with adequate intensity and duration to control and eradicate the infection, without compromise the host homeostasis. In this respect, several mechanisms are involved in the control and regulation of the immune response to prevent an exaggerated immune response to pathogens. Here, we focused on two key molecul...


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