17 documents found, page 1 of 2

Addressing the challenge of oligomerization in computational protein design

Computational protein design is a field of research with potential to greatly impact areas such as drug development or enzyme technology, by combining knowledge-based and physics-based methods to design tailor-made proteins. This concept was introduced by David Baker with the development of Rosetta Commons. This is an extensive framework containing tools that enable protein design using physics-based scoring fu...

Computationally-designed miniproteins showing neutralization activity against S...

As the COVID-19 pandemic demonstrated, the need for robust antiviral therapies against SARS-CoV-2 remains substantial. A promising strategy to meet this demand is through the development of proteins tailored for enhanced binding affinity to crucial viral targets, such as epitopes located on their fusion proteins. Among these targets is the Spike proteins receptor binding domain (RBD), which interacts with the h...

Psychological violence within a partner relationship and alcohol abuse of Portu...

In this study, we explored how psychological violence within a partner relationship relates to resilience and alcohol abuse of Portuguese women, particularly, testing the mediating role of resilience. A cross-sectional sample of 464 Portuguese women with a partner relationship was screened for psychological violence, alcohol abuse, and resilience. Results showed differences in terms of age, marital status, and ...

Bioprocess Engineering of Insect Cells for Accelarating Vacines Development

"Multimeric protein structures such as virus-like particles (VLPs) are attractive vaccine modalities due to their safety and ability to present target epitopes on their surface as repeated arrays, hence potentially eliciting a robust and broad immune response. The emergence of new viruses and virus strains raises the concern about new potential pandemic outbreaks, thus urging the continued development of produc...

Avaliação dermatológica numa população sem-abrigo

A população sem abrigo apresenta um risco aumentado de doenças dermatológicas. A vida na rua, associada a cuidados de higiene e alimentação deficitários, a elevada prevalência de comportamentos aditivos e de patologia psiquiátrica torna esta população mais vulnerável a dermatoses. A busca tardia ou insuficiente dos cuidados de saúde associados a parcos recursos económicos, compromete a realização de tratamentos...

Avaliação dermatológica e cuidados básicos de saúde numa população em situação ...

INTRODUÇÃO Pelo contexto de vida a que estão sujeitas, as pessoas em situação de sem abrigo são um grupo extremamente vulnerável a problemas de saúde diversos. Dificuldades no acesso a cuidados de saúde e por vezes, a relutância por parte deste grupo, na procura de ajuda de estruturas especializadas, fazem com que seja necessária a intervenção por profissionais de saúde junto deste grupo-alvo. A permanência na ...

Guião (in)formativo legislação violência doméstica

Guião (in)formativo avaliação de risco de violência doméstica

Manual para agentes qualificados/as de atendimento à vítima

Guião (in)formativo atendimento a vítimas especialmente vulneráveis