9 documents found, page 1 of 1
Use of statins and the risk of dementia and mild cognitive impairment: a system...
Chu, Che-Sheng; Tseng, Ping-Tao; Stubbs, Brendon; Chen, Tien-Yu; Tang, Chia-Hung; Li, Dian-Jeng; Yang, Wei-Cheng; Chen, Yen-Wen; Wu, Ching-KuanWe conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects metaanalys...
Imaging genetics paradigms in depression research: systematic review and meta-a...
Pereira, Lícia P.; Köhler, Cristiano A.; Stubbs, Brendon; Miskowiak, Kamilla W.; Morris, Gerwyn; Freitas, Bárbara P. de Freitas; Thompson, TrevorImaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixtyfive studies met eligibility criteria (N=4034 MDD participants and 3293 controls), and there was s...
Depression in cancer : the many biobehavioral pathways driving tumor progression
Bortolato, Beatrice; Hyphantis, Thomas N.; Valpione, Sara; Perini, Giulia; Maes, Michael; Morris, Gerwyn; Kubera, Marta Kubera; Köhler, Cristiano A.Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four- times higher than the general population. Depression confers worse outcomes, including non- adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer pro...
Oxidative stress and frailty : a systematic review and synthesis of the best ev...
Soysal, Pinar; Isik, Ahmet Turan; Carvalho, Andre F.; Fernandes, Brisa S.; Solmi, Marco; Schofield, Patricia; Veronese, Nicola; Stubbs, BrendonObjective Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear. We conducted a systematic review to investigate potential interactions between OS and frailty. Methods A systematic literature search of original reports providing data on ‘OS and antioxidant’ parameters and frailty was carried...
Relationship between depression and frailty in older adults : a systematic revi...
Soysal, Pinar; Veronese, Nicola; Thompson, Trevor; Kahl, Kai G.; Fernandes, Brisa S.; Prina, A. Matthew; Solmi, Marco; Schofieldk, PatriciaSOYSAL, Pinar et al. Relationship between depression and frailty in older adults : a systematic review and meta-analysis, Ageing Research, v. 36, p. 78-87, 2017.; Aim: Depression and frailty are prevalent and burdensome in older age. However, the relationships between these entities are unclear and no quantitative meta- analysis exists. We conducted a systematic review and meta-analysis to investigate the assoc...
Peripheral cytokine and chemokine alterations in depression : a meta-analysis o...
Köhler, Cristiano A.; Freitas, Thiago H.; Maes, Michael; Andrade, Nayanna Q. de; Liu, Celina S.; Fernandes, Brisa S.; Stubbs, Brendon; Solmi, M.Objective: To conduct a systematic revie w and meta -analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD ) compared to healthy controls (HCs). Method: The PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched up until May 30, 2016. Effect sizes were estimated wi th random-effects mod els. Result: Eighty-two studies comprising 3212 participants ...
The placebo and nocebo phenomena : their clinical management and impact on trea...
Chavarria, Victor; Vian, João; Pereira, Círia; Data-Franco, João; Fernandes, Brisa S.; Berk, Michael; Dodd, SeetalPurpose: This overview focuses on placebo and nocebo effects in clinical trials and routine care. Our goal was to propose strategies to improve outcomes in clinical practice, maximizing placebo effects and reducing nocebo effects, as well as managing these phenomena in clinical trials. Methods: A narrative literature search of PubMed was conducted (January 1980-September 2016). Systematic reviews, randomized co...
The renin–angiotensin system : a possible new target for depression
Vian, João; Pereira, Círia; Chavarria, Victor; Köhler, Cristiano; Stubbs, Brendon; Quevedo, João; Kim, Sung-Wan; Carvalho, André F.; Berk, MichaelDepression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin–angiotensin system have yielded promising results. Here, we review the potential bene...
Blockade of the angiotensin system improves mental health domain of quality of ...
Brownstein, Daniel J.; Salagre, Estela; Köhler, Cristiano; Stubbs, Brendon; Vian, João; Pereira, Ciria; Chavarria, Victor; Karmakar, ChandanObjective: It is unclear whether blockade of the angiotensin system has effects on mental health. Our objective was to determine the impact of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1R) blockers on mental health domain of quality of life. Study design: Meta-analysis of published literature. Data sources: PubMed and clinicaltrials.gov databases. The last search was conduct...