17 documents found, page 1 of 2
Preclinical validation of a new hybrid molecule loaded in liposomes for melanom...
Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; Mendes, EduardaThe aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifically be activated by tyrosinase, the enzyme involved in melanin biosynthesis and overexpressed in melanoma. HM displayed remarkable superior antiproliferative activity...
Antitumoral and antimicrobial activities of block copolymer micelles containing...
Sousa, Andreia; Santos, Joana F.; Silva, Francisco; Sousa, Sílvia A.; Leitão, Jorge H.; Matos, António P.; Pinheiro, Teresa; Silva, Rafaela A. L.Gold(III) bisdithiolate complexes have been reported as potential antimicrobial and antitumoral agents. The complex [Au(cdc)2]− (cdc=cyanodithioimido carbonate) displayed antimicrobial and outstanding antitumor activity against the ovarian cancer cells A2780 and A2780cisR, which are sensitive and resistant to cisplatin, respectively. However, poor water solubility may hamper its clinical use. Block copolymer mi...
Sparse designs for estimating variance components of nested factors with random...
Bailey, R. A.; Fernandes, Célia; Ramos, PauloA new class of designs is introduced for both estimating the variance components of nested factors and testing hypotheses about those variance components. These designs are flexible, and can be chosen so that the degrees of freedom are more evenly spread among the factors than they are in balanced nested designs. The variances of the estimators are smaller than those in stair nested designs of comparable size. ...
A method to minimize the sum of the variances of the estimators of the variance...
Fernandes, Célia; Ramos, PauloStair nested designs may be a good alternative to balanced nested designs since we can work with fewer observations and the amount of information for the different factors is more evenly distributed. In stair nested designs the number of treatments is the sum of the "actice" factor levels so these designs lead to a great economy. A method will be used to minimize the sum of the variances of the estimators of th...
Novel peptides derived from dengue virus capsid protein translocate reversibly ...
Neves, Vera; Silva, Frederico Aires da; Morais, Maurício; Gano, Lurdes; Ribeiro, Elisabete; Pinto, Antónia; Aguiar, Sandra; Gaspar, DianaThe delivery of therapeutic molecules to the central nervous system is hampered by poor delivery across the blood-brain barrier (BBB). Several strategies have been proposed to enhance transport into the brain, including invasive techniques and receptor-mediated transport (RMT). Both approaches have several drawbacks, such as BBB disruption, receptor saturation, and off-target effects, raising safety issues. Her...
Ensino Orientado para a Aprendizagem Baseada na Resolução de Problemas e ensino...
Morgado, Sofia Fernandes; Leite, Laurinda; Dourado, Luís; Fernandes, Célia; Silva, EleutérioO Ensino Orientado para a Aprendizagem Baseada em Problemas é uma metodologia de ensino centrada nos alunos que lhes permite aprender conhecimentos novos resolvendo problemas. O objetivo deste estudo foi comparar os contributos desse tipo de ensino, organizado segundo uma abordagem transdisciplinar, com os do ensino tradicional no que concerne à aprendizagem de conhecimentos conceituais, com diferentes níveis d...
Radiolabeled block copolymer micelles for image-guided drug delivery
Ribeiro, Elisabete; Alho, Irina; Marques, Fernanda; Gano, Lurdes; Correia, Isabel; Correia, João D. G.; Casimiro, Sandra; Costa, LuisWe aimed at exploring block copolymer micelles (BCMs) for the simultaneous delivery of radiation/chemotherapy to cancer cells. To achieve that goal, we have prepared and characterized a novel type of docetaxel (DTX) loaded and non-loaded BCMs. The micelles were decorated with pyrazolyl-diamine chelating units to stabilize the matched pair 99mTc/Re for image-guided delivery of therapeutic drugs. The in vitro stu...
Algebraic structure for interaction on mixed models
Ramos, Paulo; Fernandes, Célia; Mexia, João TiagoBinary operations on commutative Jordan algebras, CJA, can be used to study interactions between sets of factors belonging to a pair of models in which one nests the other. It should be noted that from two CJA we can, through these binary operations, build CJA. So when we nest the treatments from one model in each treatment of another model, we can study the interactions between sets of factors of the first and...
Algebraic structure for the crossing of balanced and stair nested designs
Fernandes, Célia; Ramos, Paulo; Mexia, João TiagoStair nesting allows us to work with fewer observations than the most usual form of nesting, the balanced nesting. In the case of stair nesting the amount of information for the different factors is more evenly distributed. This new design leads to greater economy, because we can work with fewer observations. In this work we present the algebraic structure of the cross of balanced nested and stair nested design...
Cobs and stair nesting – segregation and crossing
Fernandes, Célia; Ramos, Paulo; Mexia, JoãoStair nesting leads to very light models since the number of their treatments is additive on the numbers of observations in which only the level of one factor various. These groups of observations will be the steps of the design. In stair nested designs we work with fewer observations when compared with balanced nested designs and the amount of information for the different factors is more evenly distributed. W...