ABSTRACT Introduction: Europe is the world's largest producer and exporter of wine, and in recent decades, both have increased in volume and value, driven mainly by the liberalization of international trade. The increasing value of wine exports suggests that higher-quality wines are being produced, which in turn helps attract wine tourists. Wine tourism plays a crucial role in enhancing the visibility and reput...
Migraine is increasingly understood as a disorder of brain network dysfunction, where attack-related cognitive symptoms (attention deficits, slowed processing speed and executive dysfunction) can be as disabling as pain and may persist into the interictal period. Such symptoms are associated with functional and structural changes across the migraine cycle, involving the prefrontal cortex, thalamus, hypothalamus...
Certa vez, perguntei a uma criança: "Qual é a forma da Terra?" Ela respondeu: "Na sala de aula, por causa da professora, digo que a Terra é redonda. Mas quando vou de viagem, o carro nunca faz uma curva para cima e para baixo!" Este aparente paradoxo foi o ponto de partida para a elaboração deste livro, intitulado «Aprender com os conhecimentos e as experiências das crianças». A resposta espontânea da criança r...
Lignin, a natural and abundant biopolymer, holds great potential for cosmetic applications. However, its limited solubility and inherently negative charge restrict its use in certain formulations. This is particularly relevant for hair conditioning, where a positively charged polymer is preferred to effectively treat negatively charged damaged hair. To overcome this limitation, lignin extracted from acacia wood...
A investigação tem como principal desiderato analisar o potencial da Inteligência Artificial como ferramenta de inovação social no mercado do trabalho, com o propósito de identificar e propor mecanismos para promover a inclusão de diferentes grupos de trabalhadores e aprimorar a qualidade do emprego.
O Turismo Rural e as Experiências Turísticas são elementos diferenciadores para a competitividade e o desenvolvimento dos territórios rurais, proporcionando aos turistas a oportunidade de interagir com a vida rural e as tradições locais, e permitir que a população residente se envolva na atividade turística. Nesta linha de pensamento, o presente estudo tem como objetivo analisar o desenvolvimento das ilhas de S...
Paragangliomas are rare neuroendocrine tumors whose clinic and presentation depend on secretory profile, size, and location. About 40% of paragangliomas are associated with genetic syndromes with the succinate dehydrogenase enzyme complex (SDH) mutation being the most frequent. Mutation in SDHB is associated with a worse prognosis and increased risk of metastatic disease. We present a clinical case of a 45-year...
Introduction: Stroke is considered one of the greatest public health challenges worldwide, with the ischemic subtype being the most prevalent. Various acute stroke clinical guidelines recommend early rehabilitation interventions, including very early mobilization. However, despite the studies conducted in recent years regarding when to initiate mobilization after an acute stroke, there are few systematic and pe...
Purpose: Using the city of Viana do Castelo as a case study, the aim of this paper is to analyse the capacity of a city to transform itself into a Smart City. The specific objectives are: (i) to analyse the perception of the concept of Smart Cities by the different stakeholders; and (ii) to analyse the potential of Viana do Castelo to become a Smart City, considering the economic, human, living, governance, en...
Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryn...