5 documents found, page 1 of 1
Genetic ablation of inositol 1,4,5-Trisphosphate receptor type 2 (IP3R2) fails ...
Garcia, Daniela Raquel Cunha; Fernandes, Daniela Monteiro; Correia, Joana Sofia; Carvalho, Andreia Alexandra NevesSpinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3). This leads to neurodegeneration of specific brain and spinal cord regions, resulting in a progressive loss of motor function. Despite neuronal death, non-neuronal cells, including astrocytes, are also involved in SCA3 pathogenesis. Astrogliosis is a common p...
Profiling microglia in a mouse model of Machado–Joseph disease
Campos, Ana Bela; Silva, Sara Duarte; Fernandes, Bruno; Neves, Sofia Pereira das; Marques, Fernanda; Castro, Andreia Teixeira; Carvalho, Andreia NevesMicroglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remains unexplored. Here, we characterized the profile of microglia in the CMVMJD135 mouse model of MJD. This characterization was performed using primary microglial cultur...
Profiling microglia in a mouse model of Machado-Joseph disease
Campos, Ana Bela; Silva, Sara Carina Duarte; Fernandes, B.; Neves, Sofia Pereira; Marques, Fernanda; Castro, Andreia Cristiana TeixeiraMicroglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remains unexplored. Here, we characterized the profile of microglia in the CMVMJD135 mouse model of MJD. This characterization was performed using primary microglial cultur...
Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into n...
Pinheiro, Bárbara Filipa Mendes; Cunha, Carina Isabel Soares; Marote, Ana Maria Franco Aveiro; Loureiro-Campos, Eduardo; Campos, Jonas OliveiraParkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson’s disease (PD) in rodents. Despite commonly used in rats, it can be challenging to reproduce a similar lesion in mice. Moreover, there is a lac...
A positive modulator of AMPA receptors against AD pathology: in vivo studies
Fernandes, Daniela MonteiroAlzheimer’s disease (AD) is the most prevalent neurodegenerative disorder among the elderly, estimated to affect approximately 47 million people worldwide, a number that is expected to triple in just 3 decades. While the currently available drugs only temporarily improve memory and cognitive function or delay the progression of dementia, there is no effective cure at the moment with AD remaining a devastating d...