26 documents found, page 1 of 3
3D tubular constructs based on natural polysaccharides and recombinant polypept...
Rodrigues, Luísa Cidália Guimarães; Gomes, J. M.; Soares da Costa, Diana; Fernandes, Emanuel Mouta; Costa, R. R.; Rodríguez-Cabello, J. C.; Silva, S. S.The development of versatile tubular structures is critical for tissue engineering (TE) applications where vascularization is necessary. This study investigates the fabrication of tubular shaped biomaterials focused on chitosan (CHT) combined with alginate (ALG) and acemannan (ACE), known for their synergistic properties, including physical stability, antibacterial activity, and healing promotion. Translating t...
Biomateriais e Medicina Regenerativa: o papel do I3Bs numa estratégia de susten...
Silva, Tiago H.; Almeida, Mariana; Peixoto, Daniela; Fernandes, Emanuel Mouta; Alves, N. M.; Reis, R. L.[Excerto] O Instituto de Investigação em Biomateriais, Biodegradáveis e Biomiméticos, I3Bs, é a mais recente Unidade Orgânica da Universidade do Minho, surgindo em março de 2018, tendo sido uma das primeiras Unidades Orgânicas de Investigação criada no âmbito do RJIES (2007) em Universidades públicas Portuguesas. No entanto, a sua história tem origem em 1999, com a criação do Grupo de Investigação 3B’s, dedicad...
Chitosan-based hierarchical scaffolds crosslinked with genipin
Piaia, Lya; Silva, Simone S.; Fernandes, Emanuel Mouta; Gomes, Joana M.; Franco, Albina Ribeiro; Leonor, I. B.; Fredel, Márcio C.; Salmoria, Gean V.Osteochondral defects present significant challenges for effective tissue regeneration due to the complex composition of bone and cartilage. To address this challenge, this study presents the fabrication of hierarchical scaffolds combining chitosan/β-tricalcium phosphate (β-TCP) to simulate a bone-like layer, interconnected with a silk fibroin layer to mimic cartilage, thus replicating the cartilage-like laye...
Antimicrobial marine-derived materials
Silva, Simone Santos; Fernandes, Emanuel Mouta; Rodrigues, Luísa Cidália Guimarães; Reis, R. L.Currently, the next generation of natural-based antimicrobial systems has been developed, showing the potential to prevent and eliminate microorganisms in various environments. Within this context, the antibacterial activity of marine-derived polymers supports the creation of antimicrobial-based formulations as alternative strategy for antibiotic use. Marine renewable sources such as crab shells, squid pens, an...
Structure and composition of the cuticle of the goose barnacle Pollicipes polli...
Almeida, Mariana A.; Fernandes, Emanuel Mouta; Marques, Ana Catarina Fernandes; Lobo, Flávia Cristina Marques; Sousa, Rita Alexandra OliveiraArthropods, the largest animal phylum, including insects, spiders and crustaceans, are characterized by their bodies being covered primarily in chitin. Besides being a source of this biopolymer, crustaceans have also attracted attention from biotechnology given their cuticlesâ remarkable and diverse mechanical properties. The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their ...
Chitosan/virgin-coconut-oil-based system enriched with cubosomes: a 3D drug-del...
Silva, SS; Rodrigues, Luísa Cidália Guimarães; Fernandes, Emanuel Mouta; Soares da Costa, Diana; Villalva, Denise G.; Loh, Watson; Reis, R. L.Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac,...
Development of bilayered porous silk scaffolds for thymus bioengineering
Silva, Catarina S.; Kundu, Banani; Gomes, Joana M.; Fernandes, Emanuel Mouta; Reis, R. L.; Kundu, Subhas C; Martins, Albino; Neves, N. M.The thymus coordinates the development and selection of T cells. It is structured into two main compartments: the cortex and the medulla. The replication of such complex 3D environment has been challenged by bioengineering approaches. Nevertheless, the effect of the scaffold microstructure on thymic epithelial cell (TEC) cultures has not been deeply investigated. Here, we developed bilayered porous silk fibroi...
Collagen membrane from bovine pericardium for treatment of long bone defect
Yamanaka, J. S.; Oliveira, A. C.; Bastos, Ana Raquel Fernandes; Fernandes, Emanuel Mouta; Reis, R. L.; Correlo, V. M.; Shimano, A. C.The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane ...
Development of cork biocomposites enriched with chitosan targeting antibacteria...
Fernandes, Emanuel Mouta; Lobo, Flávia Cristina Marques; Faria, Sara I.; Gomes, Luciana C.; Silva, Tiago H.; Mergulhão, Filipe J. M.; Reis, R. L.The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns. In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were devel- oped using melt-based technologies. Chitosan and polyethylene-graft-maleic anhydride (PE-g-MA) were employed to enhance the CPC’s pro...
Pharmacological and non-pharmacological agents versus bovine colostrum suppleme...
Kydonaki, Eirini K.; Freitas, Laura; Reguengo, Henrique; Simón, Carlos Raposo; Bastos, Ana Raquel Fernandes; Fernandes, Emanuel MoutaOsteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month...