5 documents found, page 1 of 1
Bridging the gap between lactoferrin and V-ATPase through a multi-stage computa...
Pereira, Cátia Sofia Santos; Rocha, Juliana F.; Fernandes, Henrique S.; Rodrigues, Lígia R.; Côrte-Real, Manuela; Sousa, Sérgio F.Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities [1,2]. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton pump essential for pH homeostasis called V-ATPase. Lf-driven V-ATPase inhibition leads to cytosolic acidific...
Development of Neuropeptide Y and Cell-Penetrating Peptide MAP Adsorbed onto Li...
Silva, Sara; Marto, Joana; Gonçalves, Lídia; Fernandes, Henrique S.; Sousa, Sérgio F.; Almeida, António José; Vale, NunoFunctionalization of nanoparticles surfaces have been widely used to improve diagnostic and therapeutic biological outcome. Several methods can be applied to modify nanoparticle surface; however, in this article we focus toward a simple and less time-consuming method. We applied an adsorption method on already formulated nanostructured lipid carriers (NLC) to functionalize these nanoparticles with three distinc...
The milk-derived lactoferrin inhibits V-ATPase activity by targeting its V1 domain
Pereira, Cátia Sofia Santos; Rocha, Juliana F.; Fernandes, Henrique S.; Rodrigues, L. R.; Côrte-Real, Manuela; Sousa, Sérgio F.Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton pump called V-ATPase. Lf-driven V-ATPase inhibition leads to cytosolic acidification, ultimately causing cell deat...
LegionellaDB - A Database on Legionella Outbreaks
Gonçalves, Inês G.; Fernandes, Henrique S.; Duarte Melo, Ana; Sousa, Sérgio F.; Simões, Lúcia Chaves; Simões, Manuel LopesLegionellaDB is the first database on Legionella outbreaks; it is based on a metadata analysis of peer-reviewed manuscripts from PubMed and SCOPUS. LegionellaDB is dynamic and extensible, allowing users to search for specific outbreaks, suggest additional information to be included after curation, visualize statistical representations on specific outbreaks, and download selected data. The database is maintained...
Deciphering the interaction of lactoferrin with V-ATPase towardsa deeper unders...
Cátia S. Pereira; Rocha, Juliana F.; Fernandes, Henrique S.; Rodrigues, L. R.; Côrte-Real, Manuela; Sousa, Sérgio F.Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton pump called V-ATPase. Lf-driven V-ATPase inhibition leads to cytosolic acidification, ultimately causing cell deat...