13 documents found, page 1 of 2
A meta-analysis of epigenome-wide association studies of ultra-processed food c...
Llauradó-Pont, J; Stratakis, N; Fiorito, G; Handakas, E; Neumann, A; Barros, H; Brantsæter, AL; Chang, K; Chatzi, L; Felix, JF; Grazuleviciene, R"Background/objective: There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emerging as an important factor impacting health, but mechanisms need to be uncovered. We therefore aimed to assess the association between UPF consumption and DNA methylation in children. Methods: We conducted a meta-analysis of epigenome-wide association studies (EWAS) fro...
Life-course socioeconomic disadvantage and lung function: a multicohort study o...
Rocha, V; Fraga, S; Moreira, C; Carmeli, C; Lenoir, A; Steptoe, A; Giles, G; Goldberg, M; Zins, M; Kivimäki, M; Vineis, P; Vollenweider, P; Barros, HBackground Lung function is an important predictor of health and a marker of physical functioning at older ages. This study aimed to quantify the years of lung function lost according to disadvantaged socioeconomic conditions across the life-course. Methods This multicohort study used harmonised individual-level data from six European cohorts with information on life-course socioeconomic disadvantage and lung f...
Height and body-mass index trajectories of school-aged children and adolescents...
Horimoto, AR; Hormiga, CM; Horta, BL; Houti, L; Howitt, C; Htay, TT; Htet, AS; Htike, MMT; Hu, Y; Huerta, JM; Huhtaniemi, IT; Huidumac Petrescu, CBackground: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods: For this pooled analysis, we used a database of cardiometabolic risk factors colla...
Special Report: The Biology of Inequalities in Health: The Lifepath Consortium
Vineis, P; Avendano-Pabon, M; Barros, H; Bartley, M; Carmeli, C; Carra, L; Chadeau-Hyam, M; Costa, G; Delpierre, C; D'Errico, A; Fraga, S; Giles, GFunded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of ...
Patterning of educational attainment across inflammatory markers: Findings from...
Maurel, M; Castagné, R; Berger, E; Bochud, M; Chadeau-Hyam, M; Fraga, S; Gandini, M; Hutri-Kähönen, N; Jalkanen, S; Kivimäki, M; Marmot, M; McCrory, CBackground. Evidence suggests that the inflammatory reaction, an adaptive response triggered by a variety of harmful stimuli and conditions involved in the risk and development of many chronic diseases, is a potential pathway through which the socioeconomic environment is biologically embedded. Difficulty in interpreting the role of the inflammatory system in the embodiment dynamic arises because of heterogenei...
The contribution of sleep to social inequalities in cardiovascular disorders: a...
Petrovic, D; Haba-Rubio, J; de Mestral, Vargas, C; Kelly-Irving, M; Vineis, P; Kivimäki, M; Nyberg, S; Gandini, M; Bochud, M; Vollenweider, PAims: Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigate the role of sleep duration in the association between life-course socioeconomic status (SES...
Neighbourhood socioeconomic deprivation and allostatic load: a multi-cohort study
Ribeiro, AI; Fraga, S; Kelly-Irving, M; Delpierre, C; Stringhini, S; Kivimaki, M; Joost, S; Guessous, I; Gandini, M; Vineis, P; Barros, HLiving in deprived neighbourhoods may have biological consequences, but few studies have assessed this empirically. We examined the association between neighbourhood deprivation and allostatic load, a biological marker of wear and tear, taking into account individual’s socioeconomic position. We analysed data from three cohort studies (CoLaus-Switzerland; EPIPorto-Portugal; Whitehall II-UK) comprising 16,364 pa...
Maternal educational inequalities in measured body mass index trajectories in t...
McCrory, C; Leahy, S; Ribeiro, AI; Fraga, S; Barros, H; Avendano, M; Vineis, P; Layte, R; LIFEPATH consortiumBackground Social inequalities in the prevalence of childhood overweight and obesity are well-established, but less is known about when the social gradient first emerges and how it evolves across childhood and adolescence. Objective This study examines maternal education differentials in children's body mass trajectories in infancy, childhood and adolescence using data from four contemporary European child coho...
A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequ...
Layte, R; McCrory, C; Cheallaigh, CN; Bourke, N; Kivimaki, M; Ribeiro, AI; Stringhini, S; Vineis, PThe status anxiety hypothesis proposes that systematic inflammation as a consequence of chronic psycho-social stress is a possible pathway linking socio-economic position (SEP) to premature ageing and is a possible explanation for cross-national variation in patterns of health and well-being. Harmonised data from the LIFEPATH consortium on 18,349 individuals aged 50 to 75 and 30,632 observations are used to mea...
Allostatic load and subsequent all-cause mortality: which biological markers dr...
Castagné, R; Garès, V; Karimi, M; Chadeau-Hyam, M; Vineis, P; Delpierre, C; Kelly-Irving, MThe concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL...