134 documents found, page 1 of 14
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
Can the kindergarten teacher's behavior shape children's participation, communi...
Morais, Inês; Azevedo, Ana Rita; Fernandes, Isabel; Fuertes, MarinaEarly child development is greatly influenced by individual experiences (physical, motor, and sensory) and social interactions. Learning about how the adult interacts and communicates influences the child's actions and participation. In this research, we intend to study the adult role as a social and pedagogical model for children aged between 2 and 3 years during a joint construction play activity and understa...
Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue ...
Lopes Brás, Raquel; Muñoz Muñoz, Paula; Netto, Eduardo; Fernandez, Juan Angel; Serradilla, Mario; Lozano Lominchar, Pablo; Esperança Martins , MiguelPublisher Copyright: © 2025 by the authors.; Liver metastases from soft tissue sarcoma are very rare. The standard treatment for metastatic sarcoma is primarily based on chemotherapy, often with poor results. However, when metastases are confined to the liver and are amenable to surgery or ablative techniques, radical treatment could be an option, keeping patients disease-free and without the need for systemic ...
Succinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defi...
Esperança-Martins, Miguel; Vasques, Hugo; Ravasqueira, Manuel Sokolov; Santos, Filipa; Fonseca, Filipa; Queiroz, António Syder; Boavida, JoãoPublisher Copyright: ©2025 The Authors; Published by the American Association for Cancer Research.; Undifferentiated pleomorphic sarcoma (UPS) remains one of the most clinically aggressive and poorly characterized soft-tissue sarcoma subtypes. To uncover distinctive molecular traits for UPS, a multiomics analysis of UPS compared with leiomyosarcoma (LMS) and liposarcoma (LPS) was performed. Transcriptomic profi...
Association Between COVID-19 and the Incidence of Type 1 Diabetes in Portugal -...
Bjerregaard-Andersen, Morten; Da Silva, Jessica; Diogo, Rui; Claro, Ana Raquel; Ferro, Inês; Romana, Andreia; Rocha, Patrícia; Sá, BeatrizBackground: Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, and the incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends between COVID-19 and T1D. Methods: Hospital data, comparing the...
Exposure to Waste Anesthetic Gases Throughout Surgical Interventions: A Case St...
Leal, Leiddi Laura Maria; Yamanaka, Vanessa Yukie; Pereira, Ermelinda; Theodoro, Joseane; Domingues, Maria de Fátima; Fernandes, IsabelThe accumulation of anesthetic gas residues in surgery units can pose health risks to healthcare professionals, highlighting the need to establish effective protection measures. This study evaluated waste anesthetic gas levels in a local health unit in northern Portugal to identify highexposure areas during surgeries using general anesthesia. Measurements of desflurane, sevoflurane, carbon dioxide, air temperat...
Transcriptomic Analyses Reveal That Coffea arabica and Coffea canephora Have Mo...
Marques, Isabel; Fernandes, Isabel; Paulo, Octávio S.; Rodrigues, Ana P.; Partelli, Fábio L.; DaMatta, Fábio M.; Ribeiro-Barros, Ana I.Increasing exposure to unfavorable temperatures and water deficit imposes major con- straints on most crops worldwide. Despite several studies regarding coffee responses to abiotic stresses, transcriptome modulation due to simultaneous stresses remains poorly understood. This study unravels transcriptomic responses under the combined action of drought and temperature in leaves from the two most traded species: ...
Transcriptomic Analyses Reveal That Coffea arabica and Coffea canephora Have Mo...
Marques, Isabel; Fernandes, Isabel; Paulo, Octávio S.; Batista, Dora; Lidon, Fernando C.; Rodrigues, Ana P.; Partelli, Fábio L.; DaMatta, Fábio M.Increasing exposure to unfavorable temperatures and water deficit imposes major constraints on most crops worldwide. Despite several studies regarding coffee responses to abiotic stresses, transcriptome modulation due to simultaneous stresses remains poorly understood. This study unravels transcriptomic responses under the combined action of drought and temperature in leaves from the two most traded species: Co...
A case of success: complete response to Radium-223 in metastatic castration-res...
Soares De Pinho, Inês; Esperança Martins, Miguel; Machado, Bárbara; Dâmaso, Sara; Brás, Raquel; Cantinho, Guilhermina; Fernandes, Isabel; Costa, LuisRadium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, an...
Association between COVID-19 and the incidence of type 1 diabetes in Portugal –...
Andersen, Morten Bjerregaard; Silva, Jessica Da; Diogo,. Rui; Claro, Ana Raquel; Ferro, Inês; Romana, Andreia; Rocha, Patrícia; Sá, BeatrizBackground: Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, and the incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends between COVID-19 and T1D.MethodsHospital data, comparing the in...