2 documents found, page 1 of 1
Differential expression of MYC in H. pylori-related intestinal
Fernandes, Isabelle Joyce de Lima Silva; Alves, Markênia Kélia Santos; Lima, Valeska Portela; Lima, Marcos Antônio Pereira deEvidence suggests that the carcinogenic process guided by Helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as BCL-2, BAX, and MYC. However, the literature is conflicting regarding the expression frequency in the histological subtypes and did not consider cagA gene presence. To investigate the expression of these proteins considering the histological subtypes of gastric cance...
Helicobacter pylori e polimorfismos em enzimas de reparo de DNA e de síntese de...
Fernandes, Isabelle Joyce de Lima SilvaGastric cancer is the most deadly malignant neoplasia worldwide, with high incidence in Brazil and Helicobacter pylori infection is a well-established risk factor. Depending on the presence of virulence genes such as cagA, cagE, vacA and virB11, H. pylori can cause differentiated inflammatory responses, with large amounts of nitric oxide (NO) generated primarily by iNOS. High amount of NO resulting in accumulat...