10 documents found, page 1 of 1

Mathematical modelling of multi-product ordering in three-echelon supply chain ...

This paper proposes a mixed integer linear programming model for a multi-product ordering in a three-echelon supply chain network, where multiple manufacturers supply multiple warehouses with multiple products, which in turn distribute the products to the multiple retailers involved. The model considers practical production constraints such as production capacity, backorder allowances, and economically-viable m...

Global, regional, and national age-sex-specific mortality for 282 causes of dea...

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly availa...

New combined CFH/MCP mutations and a rare clinical course in atypical haemolyti...

Atypical haemolytic uraemic syndrome (aHUS) is a rare, life-threatening, chronic, genetic disease due to uncontrolled alternative pathway complement activation. In this report, we discuss the case of a heterozygous carrier of a mutation on both factor H and membrane cofactor protein, who persistently presents haemolytic anaemia without need for blood transfusions, normal platelet count, normal renal function an...

Dermatite de contacto alérgica profissional ao mercaptobenzotiazol

Introdução: A dermatite de contacto alérgica ao mercaptobenzotiazol e seus derivados tem sido reconhecida de forma crescente nos países industrializados devido ao seu uso alargado na polimerização da borracha sintética. Os autores descrevem dois casos clínicos com relevante exposição profissional. Caso 1: Homem de 46 anos, trabalhador na construção civil, com uma dermatite de oito meses de evolução, pruriginosa...

Recalcitrant pemphigus vulgaris: aseptic meningitis associated with intravenous...

Imunoglobulinas endovenosas em dermatologia – experiência clínica de 7 anos no ...

Introdução: Nos últimos anos tem aumentado a experiência clínica com o uso de Imunoglobulinas Endovenosas (IgEv) em Dermatologia. Apesar da informação limitada na literatura, a utilização off-label das IgEv tem demonstrado eficácia na terapêutica de várias dermatoses refratárias aos tratamentos convencionais. Material e métodos: Efetuou-se um estudo retrospetivo dos doentes com patologia dermatológica tratados ...

Efficacy and safety of etanercept in patients with psoriasis and hepatitis C

Topical Imiquimod Treatment of Lentigo Maligna

Lentigo maligna (LM) is the in situ phase of lentigo maligna melanoma, which may progress to invasive melanoma if left untreated. It mainly occurs on sun-exposed areas of elderly patients. The lesions can be large and conventional surgery can be difficult, particularly on the face. Recent reports indicate that topical imiquimod 5% cream is effective in the treatment of LM. It may be an alternative when surgery ...

Cyclosporin A treatment in severe childhood psoriasis

Though used occasionally, systemic therapies in severe childhood psoriasis have not been systematically investigated. Cyclosporin A (CysA) is effective in adults with severe psoriasis but there are no extensive data regarding the efficacy and safety of its use in childhood psoriasis. In this paper, we describe six children aged between 11 months and 13 years (average: 7.6 years) treated with CysA microemulsion ...

Lymphadenopathy after BCG vaccination in a child with chronic granulomatous dis...