4 documents found, page 1 of 1
New insights on antibacterial mode of action of blue-light photoactivated berbe...
Gonsalves, ASC; Fernandes, JR; Saavedra, MJ; Guimaraes, NM; Pereira, C; Simoes, M; Anabela Borges; Simões MAntimicrobial photodynamic inactivation (aPDI), using photosensitisers in combination with antibiotics, is a promising multi-target strategy to address antibiotic resistance, particularly in wound infections. This study aimed to elucidate the antibacterial mode of action of combinations of berberine (Ber) or curcumin (Cur) with selected antibiotics (Ber-Ab or Cur-Ab) under blue light irradiation (420 nm) agains...
Photodynamic activation of phytochemical-antibiotic combinations for combatting...
Gonçalves, ASC; Leitao, MM; Fernandes, JR; Saavedra, MJ; Pereira, C; Simoes, M; Anabela Borges; Simões MStaphylococcus aureus is characterized by its high resistance to conventional antibiotics, particularly methicillinresistant (MRSA) strains, making it a predominant pathogen in acute and chronic wound infections. The persistence of acute S. aureus wound infections poses a threat by increasing the incidence of their chronicity. This study investigated the potential of photodynamic activation using phytochemical-...
Graphene oxide topical administration: Skin permeability studies
Silva, FALS; Costa-Almeida, R; Timochenco, L; Amaral, SI; Pinto, S; Gonçalves, IC; Fernandes, JR; Magalhães, FD; Sarmento, B; Pinto, AMNanostructured carriers have been widely used in pharmaceutical formulations for der-matological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional formulations. Due to its large surface area, small size and photothermal properties, graphene oxide (GO) has the potential to be used for such applications. Nanogr...
Near-infrared radiation-based mild photohyperthermia therapy of non-melanoma sk...
Costa-Almeida, R; Bogas, D; Fernandes, JR; Timochenco, L; Silva, FALS; Meneses, J; Gonçalves, IC; Magalhães, FD; Pinto, AMUsing a one-step thermal reduction and non-covalent chemical functionalization process, PEGylated reduced nanographene oxide (rGOn-PEG) was produced from nanographene oxide (GOn) and characterized in terms of particle size, dispersion stability, chemistry, and photothermal properties, in view of its use for photothermal therapy (PTT) of non-melanoma skin cancer. GOn infrared spectrum presented more intense band...