63 documents found, page 1 of 7
Global, regional, and national prevalence of adult overweight and obesity, 1990...
GBD 2021 Adult BMI; Ng, Marie; Gakidou, Emmanuela; Lo, Justin; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; Abbas, Nasir; Abbasian, MohammadrezaBackground Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050. Methods Leveraging established methodology from the Glob...
The state of health in the European Union (EU-27) in 2019: a systematic analysi...
GBD 2019 EU State of Health Collaborators; Fernandes, João C.Background: The European Union (EU) faces many health-related challenges. Burden of diseases information and the resulting trends over time are essential for health planning. This paper reports estimates of disease burden in the EU and individual 27 EU countries in 2019, and compares them with those in 2010. Methods: We used the Global Burden of Disease 2019 study estimates and 95% uncertainty intervals for the...
Exploring yeast glucans for vaccine enhancement: sustainable strategies for ove...
Azevedo-Silva, João; Amorim, Manuela; Tavares-Valente, Diana; Sousa, Pedro; Mohamath, Randolph; Voigt, Emily A.; Guderian, Jeffrey A.; Kinsey, RobertVaccine adjuvants are important for enhancing vaccine efficacy, and although aluminium salts (Alum) are the most used, their limited ability to induce specific immune responses has spurred the search for new adjuvants. However, many adjuvants fail during product development due to manufacturability, supply, stability, or safety concerns. This work hypothesizes that protein-free yeast glucans can be used as vacc...
Modified cellulose nanocrystals encapsulating cannabigerol: a step forward in c...
Casanova, Francisca; Pereira, Carla F.; Ribeiro, Alessandra B.; Castro, Pedro M.; Martins, Eva; Freixo, Ricardo; Tavares-Valente, DianaCannabigerol (CBG) from Cannabis sativa L. is known for its anti-inflammatory, antibacterial, and antioxidant properties, showing potential against intestinal inflammation. However, its lipophilic nature limits its absorption and stability. Researchers have explored cellulose nanocrystals (CNCs) to deliver lipophilic compounds and enhance their biological outcomes. This study investigated the capability of modi...
Modulation of the berry skin transcriptome of cv. tempranillo induced by water ...
Carvalho, Luisa C; Ramos, Miguel J. N.; Faísca-Silva, David; Marreiros, Pedro; Fernandes, João C.; Egipto, Ricardo; Lopes, Carlos M.; Amâncio, SaraClimate change in the Mediterranean area is making summers warmer and dryer. Grapevine (Vitis vinifera L.) is mostly important for wine production in Mediterranean countries, and the variety Tempranillo is one of the most cultivated in Spain and Portugal. Drought decreases yield and quality and causes important economic losses. As full irrigation has negative effects on quality and water is scarce in this regio...
Biological potential and bioaccessibility of encapsulated curcumin into cetyltr...
Casanova, Francisca; Pereira, Carla F.; Ribeiro, Alessandra B.; Castro, Pedro M.; Freixo, Ricardo; Martins, Eva; Tavares-Valente, DianaCurcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they ha...
Beyond pain relief: a review on cannabidiol potential in medical therapies
Luz-Veiga, Mariana; Azevedo-Silva, João; Fernandes, João C.The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from Cannabis sativa, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for pharmacological uses due to its anti-inflammatory, antioxidant, anticonvulsant, and anxiolytic potential. The molecular mechanisms involved in CB...
Design of innovative biocompatible cellulose nanostructures for the delivery an...
Casanova, Francisca; Pereira, Carla F.; Ribeiro, Alessandra B.; Costa, Eduardo M.; Freixo, Ricardo; Castro, Pedro M.; Fernandes, João C.Poor aqueous solubility, stability and bioavailability of interesting bioactive compounds is a challenge in the development of bioactive formulations. Cellulose nanostructures are promising and sustainable carriers with unique features that may be used in enabling delivery strategies. In this work, cellulose nanocrystals (CNC) and cellulose nanofibers were investigated as carriers for the delivery of curcumin, ...
Global, regional, and national incidence of six major immune-mediated inflammat...
GBD 2019 IMID Collaborators; Wu, Dongze; Jin, Yingzhao; Xing, Yuhan; Abate, Melsew Dagne; Abbasian, Mohammadreza; Abbasi-Kangevari, MohsenBackground: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, an...
Developmental Regulation of Transcription in Touriga Nacional Berries under Def...
Carvalho, Luísa C.; Ramos, Miguel N.J.; Faísca-Silva, David; van der Kellen, D.; Fernandes, João C.; Egipto, Ricardo; Lopes, C.M.; Amâncio, SaraGrapevine (Vitis vinifera L.) is one of the most economically important crops worldwide, especially due to the economic relevance of wine production. Abiotic stress, such as drought, may contribute to low yield, shifts in quality, and important economic loss. The predicted climate change phenomena point to warmer and dryer Mediterranean environmental conditions; as such, it is paramount to study the effects of ...