2 documents found, page 1 of 1
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation...
Lemos, Henrique Paula; Grespan, Renata; Manfredo Vieira, Silvio; Cunha, Thiago Mattar; Verri, Waldiceu A.; Fernandes, Karla S.; Souto, Fabrício OliveiraIL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-...
Plasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovasc...
Luizon, Marcelo R. [UNESP]; Belo, Vanessa A.; Fernandes, Karla S.; Andrade, Vanessa L.; Tanus-Santos, Jose E.; Sandrim, Valeria C. [UNESP]Made available in DSpace on 2018-12-11T17:02:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-06-01; Plasma matrix metalloproteinase (MMP)-9 is a predictor of cardiovascular mortality, and MMP-9 polymorphisms affect plasma MMP-9 levels. However, no study examined whether MMP-9 haplotypes affect MMP-9 levels in obese adults. We examined whether MMP-9 polymorphisms and haplotypes are associated with obes...