11 documents found, page 1 of 2
Charting the path: navigating embryonic development to potentially safeguard ag...
Bragança, José; Pinto, Rute L.; Silva, Barbara S.; Marques, Nuno; Leitao, Helena; Fernandes, Mónica T.Congenital heart diseases (CHDs) are structural or functional defects present at birth due to improper heart development. Current therapeutic approaches to treating severe CHDs are primarily palliative surgical interventions during the peri- or prenatal stages, when the heart has fully developed from faulty embryogenesis. However, earlier interventions during embryonic development have the potential for better ...
Human stem cells for cardiac disease modeling and preclinical and clinical appl...
Correia, Cátia; Ferreira, Anita; Fernandes, Mónica T.; Silva, Bárbara M.; Esteves, Filipa; Leitao, Helena; Bragança, José; Calado, SofiaCardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have ...
Post-transcriptional silencing of Bos taurus prion family genes and its impact ...
Pimenta, Jorge M.; Pires, Virgínia M.; Nolasco, Sofia; Castelo-Branco, Pedro; Marques, Carla C.; Apolónio, Joana; Azevedo, Rita; Fernandes, Mónica T.Prion proteins constitute a major public health concern, which has partly overshadowed their physiological roles in several scenarios. Indeed, these proteins were implicated in male fertility but their role in female fertility is relatively less explored. This study was designed to evaluate the role of SPRN and PRNP prion family genes in bovine follicular steroidogenesis pathways. Post-transcriptional SPRN and ...
Peritoneal protein loss, inflammation, and nutrition: refuting myths
Malho Guedes, A.; Calças Marques, Roberto; Ribeiro, Brigitte; Fernandes, Mónica T.; Faísca, Marília; Silva, Ana Paula; Bragança, JoséPeritoneal protein loss (PPL) has been correlated with mortality, malnutrition and inflammation. More recently overhydration was brought to the equation. This study aims to review classic and recent factors associated with PPL. Prevalent and incident peritoneal dialysis (PD) patients were included. Dialysate and serum IL-6 was obtained during PET. Hydration and nutritional status were assessed by bio-impedance....
Cdkn2a inactivation promotes malignant transformation of mouse immature thymocy...
Catarino, Telmo A.; Pacheco-Leyva, Ivette; Kindi, Faiza Al; Ghezzo, Marinella N.; Fernandes, Mónica T.; Costa, Telma; Rodrigues Dos Santos, NunoCDKN2A deletion is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia (T-ALL), occurring across all molecular and immunophenotypic subtypes. CDKN2A encodes two functionally unrelated tumor suppressor proteins, ARF and INK4a, which are critical regulators of cell cycle and proliferation. Arf has been reported to suppress T-ALL development in post−b-selection thymocytes, but whether CDKN2...
THOR is a targetable epigenetic biomarker with clinical implications in breast ...
Apolónio, Joana; Dias, João S.; Fernandes, Mónica T.; Komosa, Martin; Lipman, Tatiana; Zhang, Cindy H.; Leão, Ricardo; Lee, Donghyun; Nunes, Nuno M.Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demon‑ strate the urgent need of novel and more efective diagnostic and therapeutic options. Limitless self-renewal is a hallmark of cancer, governed by telomere maintenance. In around 95% of BC cases, this proces...
Post-transcriptional silencing of Bos taurus prion family genes and its impact ...
Pimenta, Jorge M.B.G.A.; Pires, Virgínia M.R.; Nolasco, Sofia; Castelo-Branco, Pedro; Marques, Carla C.; Apolónio, Joana; Azevedo, RitaPrion proteins constitute a major public health concern, which has partly overshadowed their physiological roles in several scenarios. Indeed, these proteins were implicated in male fertility but their role in female fertility is relatively less explored. This study was designed to evaluate the role of SPRN and PRNP prion family genes in bovine follicular steroidogenesis pathways. Post-transcriptional SPRN and ...
Tribbles gene expression profiles in colorectal cancer
Fernandes, Mónica T.; Yassuda, Victor; Bragança, José; Link, Wolfgang; Ferreira, Bibiana; De Sousa-Coelho, Ana LuísaColorectal cancer (CRC) is the third most common cancer and the second leading cause of death due to cancer in the world. Therefore, the identification of novel druggable targets is urgently needed. Tribbles proteins belong to a pseudokinase family, previously recognized in CRC as oncogenes and potential therapeutic targets. Here, we analyzed the expression of <i>TRIB1</i>, <i>TRIB2</i>, and <i>TRIB3</i> simult...
Context-dependent roles for lymphotoxin-beta receptor signaling in cancer devel...
Fernandes, Mónica T.; Dejardin, Emmanuel; Rodrigues Dos Santos, NunoThe LT alpha(1)beta(2) and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LT beta R). Interestingly, since the discovery of these proteins, accumulating evidence has pinpointed a role for LT beta R signaling in carcinogenesis. Early studies have shown a potential anti-tumoral role in a subset of solid cancers either by...
Lymphotoxin-β receptor in microenvironmental cells promotes the development of ...
Fernandes, Mónica T.; Ghezzo, Marinella N.; Silveira, André B.; Kalathur, Ravi K.; Póvoa, Vanda; Ribeiro, Ana R.; Brandalise, Sílvia R.Lymphotoxin-mediated activation of the lymphotoxin-β receptor (LTβR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-α and LTβ (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (...