9 documents found, page 1 of 1
In situ formation of alginic acid‐gold nanohybrids for application in cancer ph...
Figueiredo, André Q.; Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Correia, I.J.; Moreira, André F.Gold-based nanoparticles present excellent optical properties that propelled their widespread application in biomedicine, from bioimaging to photothermal applications. Nevertheless, commonly employed manufacturing methods for gold-based nanoparticles require long periods and laborious protocols that reduce cost-effectiveness and scalability. Herein, a novel methodology was used for producing gold-alginic acid n...
Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy
Figueiredo, André Q.; Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Correia, I.J.; Moreira, AndréMetallic-based nanoparticles present a unique set of physicochemical properties that support their application in different fields, such as electronics, medical diagnostics, and therapeutics. Particularly, in cancer therapy, the plasmonic resonance, magnetic behavior, X-ray attenuation, and radical oxygen species generation capacity displayed by metallic nanoparticles make them highly promising theragnostic sol...
Cell‐Derived Vesicles for Nanoparticles' Coating: Biomimetic Approaches for Enh...
Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Correia, I.J.; Moreira, André F.Cancer nanomedicines are designed to encapsulate different therapeuticagents, prevent their premature release, and deliver them specifically tocancer cells, due to their ability to preferentially accumulate in tumor tissue.However, after intravenous administration, nanoparticles immediatelyinteract with biological components that facilitate their recognition by theimmune system, being rapidly removed from circu...
Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nan...
Fernandes, Natanael; Rodrigues, Carolina F; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André FCancer light-triggered hyperthermia mediated by nanomaterials aims to eliminate cancer cells by inducing localized temperature increases to values superior to 42 °C, upon irradiation with a laser. Among the different nanomaterials with photothermal capacity, the gold-based nanoparticles have been widely studied due to their structural plasticity and advantageous physicochemical properties. Herein, a novel and s...
Combinatorial delivery of doxorubicin and acridine orange by gold core silica s...
Guimarães, Rafaela; Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Ferreira, Paula; Correia, I.J.; Moreira, André F.Combinatorial therapies based on the simultaneous administration of multiple drugs can lead to synergistic effects, increasing the efficacy of the cancer therapy. However, it is crucial to develop new delivery systems that can increase the drugs' therapeutic selectivity and efficacy. Gold core silica shell (AuMSS) nanoparticles present physicochemical properties that allow their simultaneous application as drug...
Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nan...
Fernandes, Natanael; Rodrigues, Ana Carolina Félix; Diogo, Duarte de Melo; Correia, I.J.; Moreira, AndréCancer light-triggered hyperthermia mediated by nanomaterials aims to eliminate cancer cells by inducing localized temperature increases to values superior to 42 C, upon irradiation with a laser. Among the different nanomaterials with photothermal capacity, the gold-based nanoparticles have been widely studied due to their structural plasticity and advantageous physicochemical properties. Herein, a novel and st...
HA/PEI-coated acridine orange-loaded gold-core silica shell nanorods for cancer...
Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Ferreira, Paula; Correia, I.J.; Moreira, AndréAims: To develop a tumor-targeted chemo-photothermal nanomedicine through the functionalization of acridine orange (AO)-loaded gold-core mesoporous silica shell (AuMSS) nanorods with polyethylenimine (PEI) and hyaluronic acid (HA). Methods: Functionalization of the AuMSS nanorods was achieved through the chemical linkage of PEI followed by electrostatic adsorption of HA. Results: HA functionalization improved A...
IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targ...
Gonçalves, Ariana; Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Ferreira, Paula; Moreira, André F.; Correia, I.J.Gold core silica shell (AuMSS) nanorods present excellent physicochemical proper-ties that allow their application as photothermal and drug delivery agents. Herein,AuMSS nanorods were dual‐functionalized with Polyethylene glycol methyl ether(PEG‐CH3) and Gelatin (GEL) to enhance both the colloidal stability and uptake byHeLa cancer cells. Additionally, the AuMSS nanorods were combined for the firsttime with IR7...
Overview of the application of inorganic nanomaterials in cancer photothermal t...
Fernandes, Natanael; Rodrigues, Ana Carolina Félix; Moreira, André F.; Correia, I.J.Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect. In this field, nanomaterials capable of converting the energy of the irradiation light into heat have been showing promising results in several pre-clinical and clinical assays. Such a therapeutic modality takes advantage of the innate capacity of nanomaterials to ...