46 documents found, page 1 of 5
How useful is contrast-enhanced ultrasound in rheumatoid arthritis? A systemati...
Polido Pereira, Joaquim; António, Manuel; Henriques, Susana Oliveira; Sabido, João; Fernandes, Ricardo M.; Vieira de Sousa, Elsa CristinaObjective The primary objective was to evaluate the additional benefits of contrast-enhanced ultrasound (CEUS) compared to unenhanced Doppler ultrasound (DUS) for the identification of active synovitis in rheumatoid arthritis (RA). Methods We searched PubMed/MEDLINE and EMBASE (February 2024) for all English-written published reports of human studies including the use of CEUS for the study of synovitis in RA. T...
Analysis of the asthma scores recommended in guidelines for children presenting...
Gray, Charmaine; Collings, Madeline; Benito, Javier; Velasco, Roberto; Lyttle, Mark D.; Roland, Damian; Schuh, Suzanne; Shihabuddin, Bashar; Kwok, MariaRationale: While there are numerous published paediatric asthma scores, it is unknown how commonly scores are recommended in asthma guidelines across different geographical regions globally, and what their validation status is. Objectives: (1) To describe which clinical guidelines recommend asthma scores across different geographical regions. (2) To describe the initial and subsequent validation of the commonly...
Developments in the design, conduct, and reporting of child health trials
Baba, Ami; Aregbesola, Alex; Caldwell, Patrina H.Y.; Elliott, Sarah A.; Elsman, Ellen B.M.; Fernandes, Ricardo M.; Hartling, Lisa; Heath, AnnaTo identify priority areas to improve the design, conduct, and reporting of pediatric clinical trials, the international expert network, Standards for Research (StaR) in Child Health, was assembled and published the first 6 Standards in Pediatrics in 2012. After a recent review summarizing the 247 publications by StaR Child Health authors that highlight research practices that add value and reduce research "was...
Harmonizing quality improvement metrics across global trial networks to advance...
Attar, Sabah; Price, Angie; Hovinga, Collin; Stewart, Breanne; Lacaze-Masmonteil, Thierry; Bonifazi, Fedele; Turner, Mark A.; Fernandes, Ricardo M.Background: Despite global efforts to improve paediatric clinical trials, significant delays continue in paediatric drug approvals. Collaboration between research networks is needed to address these delays. This paper is a first step to promote interoperability between paediatric networks from different jurisdictions by comparing drivers for, and content of, metrics about clinical trial conduct. Methods: Three ...
Economic evaluations of medical devices in paediatrics: a systematic review and...
Mascarenhas, Edgar; Miguel, Luís Lopes Madureira Silva; Oliveira, Mónica D.; Fernandes, Ricardo M.Background: Although economic evaluations (EEs) have been increasingly applied to medical devices, little discussion has been conducted on how the different health realities of specific populations may impact the application of methods and the ensuing results. This is particularly relevant for pediatric populations, as most EEs on devices are conducted in adults, with specific aspects related to the uniqueness ...
Development and performance of the c4c national clinical trial networks for opt...
Degraeuwe, Eva; van der Geest, Tessa; Persijn, Laura; Nuytinck, Lieve; Raes, Ann; Turner, Mark; Fernandes, Ricardo M.; Vande Walle, JohanIntroduction: The high failure rate of industry-driven pediatric clinical trials leads to insufficient timely labeling of drugs in children and a lack of scientific evidence, resulting in the persistently high off-label drug use. National clinical trial networks can facilitate collaboration between sites, investigators, and experts, increasing the likelihood of successful trials. Within the conect4children (c4c...
Systematic reviews and meta-analysis published in indexed Portuguese medical jo...
Prada, Luísa; Prada, Ana Raquel Russo; Antunes, Miguel Marques; Fernandes, Ricardo M.; Costa, João; Ferreira, Joaquim J.; Caldeira, DanielOver the last years, the number of systematic reviews published is steadily increasing due to the global interest in this type of evidence synthesis. However, little is known about the characteristics of this research published in Portuguese medical journals. This study aims to evaluate the publication trends and overall quality of these systematic reviews. Material and methods: This was a methodological study....
Histology-agnostic drugs: a paradigm shift: a narrative review
Mansinho, André; Fernandes, Ricardo M.; Carneiro, António VazCancer diagnosis and therapeutics have been traditionally based on pathologic classification at the organ of origin. The availability of an unprecedented amount of clinical and biologic data provides a unique window of opportunity for the development of new drugs. What was once treated as a homogeneous disease with a one-size-fits-all approach was shown to be a rather heterogeneous condition, with multiple targ...
The sham effect of invasive interventions in chronic coronary syndromes: a syst...
Palma, Catarina; David, Cláudio; Fernandes, Ricardo M.; Pinto, Fausto J.; Costa, João; Ferreira, Joaquim J; Caldeira, DanielBackground: Some patients with chronic coronary syndromes undergo invasive procedures but the efficacy of such interventions remains to be robustly established by randomised sham-controlled trials (RCTs). Purpose: To determine the sham effect in patients with chronic coronary syndromes enrolled in RCTs by performing a systematic review and meta-analysis. Methods: In April 2022, we performed a literature search ...
Systematic reviews and meta-analysis published in indexed Portuguese medical jo...
Prada, Luísa; Prada, Ana; Marques Antunes, Miguel; Fernandes, Ricardo M.; Costa, João; Ferreira, Joaquim J; Caldeira, DanielIntroduction: Over the last years, the number of systematic reviews published is steadily increasing due to the global interest in this type of evidence synthesis. However, little is known about the characteristics of this research published in Portuguese medical journals. This study aims to evaluate the publication trends and overall quality of these systematic reviews. Material and methods: This was a methodo...