Background: A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients generally have poorly controlled diabetes and require extremely high doses of insulin. There is no documentation in the literature of cases of COVID in CGL patients. Thus, we aimed to evaluate the p...
Purpose: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the absence of functional adipocytes resulting in ectopic lipid storage, metabolic disorders and early cardiovascular disease. Two-dimensional speckle-tracking (2D-STE) allows the detection of early abnormalities in myocardial function. We aimed to evaluate myocardial deformation in a large sample of CGL ...
Hyperglycemia is a frequent complication and its prevalence occurs in up to 38% of hospitalized patients. Such condition may be due to previously known diabetes, stress responsive to associated diseases or treatments or it may due to diabetes only diagnosed during hospitalization. The presence of nosocomial hyperglycemia is associated with prolonged hospitalization time, increased demand for human resources and...
Background: Chikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 deaths. The clinical manifestations, pathogenesis and risk factors for occurrence of severe cases are not yet well understood, although it is known that the severity of the cases is associated ...
Objetivo: avaliar a ocorrência da polifarmácia e sua associação com a adesão ao tratatamento farmacológico em pacientes com diabetes mellitus tipo 2. Métodos: estudo transversal realizado com 235 portadores de diabetes mellitus tipo 2 por meio de entrevista sobre os dados sociodemográficos e clínicos, a terapêutica medicamentosa prescrita e a adesão ao tratamento. Para análise dos dados foram utilizados os test...
Objective: to evaluate the occurrence of polypharmacy and its association with the adherence to the pharmacological treatment in patients with diabetes mellitus type 2. Methods: cross-sectional study conducted with 235 patients with diabetes mellitus type 2 through interview about the demographic and clinical data, drug therapy prescribed and adherence to treatment. To analyze the data, we used Student t-tests ...
Objective: to evaluate the occurrence of polypharmacy and its association with the adherence to the pharmacological treatment in patients with diabetes mellitus type 2. Methods: cross-sectional study conducted with 235 patients with diabetes mellitus type 2 through interview about the demographic and clinical data, drug therapy prescribed and adherence to treatment. To analyze the data, we used Student t-tests ...
Congenital generalized lipodystrophy (CGL) is a rare, autosomal recessive disease, characterized by total or almost total absence of adipose tissue since birth. Mutations in the BSCL1/AGPAT2 and BSCL2/Seipin genes account for 95% of cases. CGL courses with severe insulin resistance (IR), diabetes mellitus (DM) and dyslipidemia, which may culminate in atherosclerosis and premature cardiovascular mortality. Howev...
Testicular tumors are a rare condition associated with congenital adrenal hyperplasia (CAH), originated from intratesticular adrenal rest tumors, and they are rarely associated with malignant tumors. Their histological differentiation from Leydig-cell tumors is quite difficult, which would lead to inappropriate orchiectomies. Thus the objective of this report was to present this diagnostic dilemma. Methods: Rep...