Candida albicans, a commensal opportunistic pathogen, exhibits remarkable metabolic flexibility and adaptability to environmental changes. In glucose-limited niches, it utilizes alternative carbon sources such as carboxylic acids, which may influence its pathogenicity. In Saccharomyces cerevisiae, the uptake of monocarboxylates occurs through regulated plasma membrane (PM) transport proteins, such as Ato1 (Ady2...
The fungal pathogen Candida albicans colonizes the human gut, where short-chain fatty acids (SCFAs) serve as a source of carbon. This fungus harbors one of the largest microbial families of ATO (acetate transporter ortholog) genes, which encode putative SCFA transport proteins. Here, we generate C. albicans null mutants lacking individual or all known putative SCFA transporter genes and compare their phenotypes...
ABSTRACT: In this work, a compact and low-cost electrochemical laboratory prototype for the storage and production of hydrogen, based on metallic hydrides, with high reversibility in the charge/discharge process is demonstrated, using electricity either from the grid or by direct coupling to renewable energies as power source. The reactor is a 316 L stainless steel vessel with a capacity up to 15 bar internal p...
ABSTRACT: The development of systems for production and storage of hydrogen as an energy vector for various applications, has gained much relevance in recent years as it is considered critical in the increase of renewable energies in the energy mix. Presently, most part of the hydrogen production using renewable energy sources is based on electrolysis systems that use water to obtain green hydrogen, that can be...
ABSTRACT: The production of hydrogen by photocatalysis presents attractive features but also stringent requirements of materials properties. A series of TiO2-based photocatalysts containing reduced graphene oxide (rGO) and plat-inum, TiO2-rGO(x)-Pt(y) (x=0-5 wt%; y=1.5, 2.5, 3.8 wt%), were synthesized by a simple two-step procedure. The ternary composites exhibited promising performance for hydrogen generation,...
As quantum computing approaches its first commercial implementations, quantum simulation emerges as a potentially ground-breaking technology for several domains, including biology and chemistry. However, taking advantage of quantum algorithms in quantum chemistry raises a number of theoretical and practical challenges at different levels, from the conception to its actual execution. We go through such challenge...
RESUMO: Neste trabalho foram sintetizados uma série de novos compósitos de TiO2-rGO e TiO2-g-C3N4, como base para o desenvolvimento de fotocatalisadores ativos na produção de hidrogénio solar a partir de soluções aquosas de etanol. Os compósitos foram dopados com metais nobres e de transição (Pt, Au e Cu), tendo sido estes fotodepositados a partir dos respetivos sais. Para 6 h de irradiação UV, o volume de gás ...
RESUMO: Um protótipo laboratorial constituído por um sistema eletroquímico compacto de produção e armazenamento, baseado em hidretos metálicos e de elevada reversibilidade no processo carga/descarga é demonstrado. O reator, fabricado em aço inoxidável 316L com capacidade até 15 bar de pressão interna, é constituído por elétrodos de trabalho de LaNi5 modificado (após substituição do Ni com pequenas quantidades d...