9 documents found, page 1 of 1
THE IMPACT OF LIVER SURGERY AND MARGIN STATUS ON SURVIVAL ACCORDING TO KRAS MUT...
Peyroteo, Mariana; Canotilho, Rita; Sousa, Alexandre; Sousa, Fernanda; Fernandes, Manuel; Gonçalves, Belarmino; Videira, José Flávio; Fragoso, MariaIntroduction: The impact of kirsten rat sarcoma viral oncogene homolog (KRAS) mutational status on surgery planning for colorectal liver metastases (CRLM) remains unknown. The aim of the study was to evaluate the impact of type of liver surgery and margin status in recurrence free survival (RFS) of patients with CRLM, according to KRAS mutational status. Materials and methods: Retrospective review of all patien...
Opioids for Cancer Pain and its Use under Particular Conditions: A Narrative Re...
Vieira, Cláudia; Brás, Marta; Fragoso, MariaIntroduction: All health professionals should be aware of the importance of evaluating pain - fifth vital sign- in cancer patients. Peripheral and central acting analgesics are widely used to treat moderate to severe pain, particularly cancer pain. Many guidelines have addressed this issue. However, real life patients’ have other problems and comorbidities that may raise doubts when prescribing.Material and Met...
Single Centre Prospective Study of Systematic Pain Evaluation in Portuguese Pat...
Sequeira, Maria Inês; Sousa, Nuno; Fragoso, Maria; Silva, Alexandra; Pereira, Filipa; Azevedo, LuísIntroduction: Pain is one of the most common symptoms reported by cancer patients and is associated with decreased quality of life. Assessment of pain with standardized questionnaires reduces variability in its interpretation and may increase effectiveness of medical interventions. Prostate cancer is the most frequent male neoplasm in Portugal. We designed this study to evaluate the impact of a standardized pai...
Guidelines for diagnostic and treatment of gastric adenocarcinoma (Digestive Ca...
Brito, Donzília; Raimundo, Ana; Sousa, Olga; Ribau, Eneida; Afonso, Luís Pedro; Cabral, Sónia; Dinis-Ribeiro, Mário; Nogueira, Carlos; Barroso, Sérgio.; .
Association between EGF +61A/G polymorphism and gastric cancer in Caucasians
Araújo, Ana Paula; Costa, Bruno Marques; Correia, Ana L. Pinto; Fragoso, Maria; Ferreira, Paula; Ribeiro, Mário Dinis; Costa, Sandra Maria Araújo daTo investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 control...
E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations c...
Oliveira, Carla; Ferreira, Paulo; Nabais, Sérgio; Campos, Luísa; Ferreira, Ana; Cirnes, Luís; Alves, Catarina Castro; Veiga, Isabel; Fragoso, MariaApproximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds remain genetically unexplained and are probably caused by alterations in other genes. Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gas...
Recommendations for follow-up of patients treated for colorectal cancer
Costa, Nuno Matos; Coutinho, Camila; Raimundo, Ana Cristina; Fragoso, Maria; Sanches, EvaristoColorectal cancer is the second more frequent cancer both in men and women. Treated patients have a high recurrence rate, making follow up an essential step for early recurrence recognition. Follow up strategies vary both between countries and between institutions within countries. As a whole, these strategies seek to improve 1) global survival; 2) quality of life; and 3) cost-benefit. The authors present a fol...
Myths about morphine
Fragoso, MariaUndertreatment of chronic pain persists as a major health issue. A number of reasons have been identified and professional and public misconceptions towards opioid prescription may be one of the main problems. Based on the questions asked by health staff and patients, a summary of what is called morphine myths is presented.; O subtratamento da dor crónica continua a assumir uma dimensão importante, colocando-a ...
Pain - a forgotten reality
Fragoso, MariaMost of us will experience pain during our lives. Although it has been considered of little importance, we are now recognising pain as a major public health issue. Cancer pain, due to the obvious rising incidence of cancer, is a well-known problem of all those who deal with these patients. While effective pain management for individual patients is obviouslyimportant, improving pain management generally will req...