3 documents found, page 1 of 1
Mutation screening in the genes PAX-8, NKX2-5, TSH-R, HES-1 in cohort of 63 Bra...
Cerqueira,Taíse Lima de Oliveira; Ramos,Yanne Rocha; Strappa,Giorgia Bruna; Jesus,Mariana Souza de; Santos,Jailciele Gonzaga; Sousa,CamilaABSTRACT Objective: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. Subjects and methods: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realize...
Transtorno de estresse pós-traumático em veteranos de guerra: uma revisão integ...
Silva,André da; Carvalho,Aymê Christina de; Francisco,Marcio; Fernandes,Vladimir; Oliveira,Maria Cristina de; Porto,Fernando; Nassar,PedroO presente aborda a influência do Transtorno de Estresse Pós Traumáticos (TEPT) diante do cotidiano dos veteranos de guerra. O estudo se faz relevante ao contexto atual mediante a falta de investigação sobre o tema, e em razão da atual conjuntura internacional, em que eventos relacionados aos conflitos bélicos estão presentes dentro da perspectiva micro e macro em uma escala de impacto social. Deste modo, se te...
The c.63A>G polymorphism in the NKX2.5 gene is associated with thyroid hypop...
Cerqueira,Taise Lima de Oliveira; Ramos,Yanne; Strappa,Giorgia; Martin,Daniel San; Jesus,Mariana; Gonzaga,Jailciele; Ferreira,Paulo; Costa,AnabelObjective To search for genetic alteration in NKX2.5 gene in patients presenting both congenital heart disease (CHD) and TD. Subjects and methods Individual phenotypes were carefully analyzed in 86 children with thyroid dysgenesis (TD) using thyroid function tests, scintigraphy, ultrasound and echocardiography. DNA was extracted and NKX2.5 gene coding region was amplified by polymerase chain reaction (PCR) and ...