4 documents found, page 1 of 1
In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttle...
Pereira, Patrícia; Neto, Ana S.; Rodrigues, Ana Sofia; Barros, Inês; Miranda, Catarina O.; Santos, João Ramalho; Almeida, Luís Pereira deThis study investigates the osteogenic differentiation of umbilical-cord-derived human mesenchymal stromal cells (hUC-MSCs) on biphasic calcium phosphate (BCP) scaffolds derived from cuttlefish bone doped with metal ions and coated with polymers. First, the in vitro cytocompatibility of the undoped and ion-doped (Sr2+, Mg2+ and/or Zn2+) BCP scaffolds was evaluated for 72 h using Live/Dead staining and viability...
Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multi...
Neto, Ana S.; Pereira, Patrícia; Fonseca, Ana C.; Dias, Carla; Almeida, Mariana C.; Barros, Inês; Miranda, Catarina O.; Almeida, Luís P. deThe present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers—poly("-caprolactone) (PCL) or poly(ester urea) (PEU)—loaded with an antibiotic drug, Rifampicin (RFP). The amounts of RFP incorporated into the PCL and PEU-coated scaffolds were 0.55 0.04 and 0.45 0.02 wt%, respectively. The in vitro drug release profiles in phosphate buffered salin...
Chitosan and polyethylene glycol based membranes with antibacterial properties ...
Pereira, Inês C.; Duarte, Ana S.; Neto, Ana S.; Ferreira, J. M. F.The prevention of microbial infections associated with implantable medical devices and superficial wounds represents one of the main research strategies in the field of biomaterials. The present study reports on the development of composite membranes of Chitosan (CS)-Polyethylene glycol (PEG) matrix, incorporating particles of biphasic calcium phosphate (BCP), zinc oxide (ZnO) and copper oxide (CuO). The proper...
Surface functionalization of cuttlefish bone-derived biphasic calcium phosphate...
Neto, Ana S.; Fonseca, Ana C.; Abrantes, J. C. C.; Coelho, Jorge F. J.; Ferreira, José M. F.Cuttlefish bone (CB) has been explored as biomaterial in the bone tissue-engineering field due to its unique porous structure and capacity of the aragonite mineral to be hydrothermally converted into calcium phosphates (CaPs). In the present study, undoped and ion (Sr2+, Mg2+ and/or Zn2+) doped biphasic calcium phosphate (BCP) scaffolds were prepared by hydrothermal transformation (HT, 200 °C, 24 h) of CB. The ...