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Assessing methodological quality of systematic reviews with meta-analysis about...

Rotta, I; Diniz, JA; Fernandez-Llimos, F

Background: Systematic reviews are critical for evidence-based healthcare decisions, but their validity depends on the quality of conduct and reporting. AMSTAR-2, a widely used tool for assessing the quality of systematic reviews, identifies seven critical domains influencing review validity, although its developers recommend flexibility in prioritizing these domains. To date, no studies have analyzed the impac...


Comparison of Electronic Prescription Systems in the European Union: Benchmarki...

Bruthans, J; Duftschmid, G; Hammar, T; Kardas, P; Bertalan, L; Hug, MJ; Büllow, C; Muscat, HA; Lilleväli, A; Jormanainen, V; Fernandez-Llimos, F

While Electronic Prescription Systems (EPS) adoption varies across EU Member States, there's a lack of comprehensive comparative analysis. Existing studies focus on single EPSs, employ diverse methodologies, and lack up-to-date data. This study fills this gap by providing a comprehensive overview of EPS development, functionalities, and usage statistics in each EU Member State. Most EU Member States widely adop...


Descentralização do acesso a medicamentos do Componente Especializado da Assist...

Rossignoli, P; Pontarolli, D; Limberger, PM; Pontarolo, R; Fernandez-Llimos, F

<jats:p>O Componente Especializado da Assistência Farmacêutica contempla medicamentos para tratamento de doenças crônicas, incluindo doenças raras, no âmbito do Sistema Único de Saúde. As secretarias estaduais de saúde são responsáveis pelo acesso a esses medicamentos. No Paraná, originalmente os locais de acesso se limitavam aos 22 municípios-sede de regionais de saúde. O objetivo deste estudo foi descrever a ...


Medicines for the management of overweight and obesity: A systematic review wit...

Marcon, GM; Paiva, JM; Sakiyama, MD; Tonin, FS; Fernandez-Llimos, F; Virtuoso, S; Sanches, AC

To synthesize the evidence about pharmacologic treatment of obesity and overweight and to define the options with the best risk-benefit using the stochastic analysis of multicriteria acceptability (SMAA). The analysis addresses a systematic review (PROSPERO CRD42023423308) whose research was realized in PubMed, Scopus, and Web of Science. Randomized controlled trials were included, which verified the effects of...


The International Collaboration of Pharmacy Journal Editors (ICPJE) formally co...

Costa, FAD; Fernandez-Llimos, F; Desselle, S; Arnet, I; Babar, Z; Bond, C; Cordina, M; Cardenas, VG; El Hajj, MS; Jacobsen, R; Law, AV; Norgaard, LS


The International Collaboration of Pharmacy Journal Editors (ICPJE) formally co...

da Costa, FA; Fernandez-Llimos, F; Desselle, S; Arnet,; Babar, Z; Bond, C; Cordina, M; Cardenas, VG; El Hajj, MS; Jacobsen, R; Law, A; Norgaard, LS


Variabilidade nos preços de aquisição pública de medicamentos do grupo 1A do co...

Rossignoli, P; Pontarolo, R; Fernandez-Llimos, F

<jats:p>Resumo Objetivo Avaliar a diferença nos preços de aquisição de medicamentos do grupo 1A do Componente Especializado da Assistência Farmacêutica entre as compras realizadas pelo Ministério da Saúde e as realizadas pela Secretaria de Estado da Saúde do Paraná. Métodos Tratou-se de estudo observacional retrospectivo comparando preços de medicamentos adquiridos centralizadamente pelo Ministério da Saúde e a...


Variability in public procurement prices for Group 1A drugs in the specialized ...

Rossignoli, P; Pontarolo, R; Fernandez-Llimos, F

Objective: To assess the difference in acquisition prices of Group 1A drugs in the Specialized Pharmaceutical Component between purchases made by the Brazilian Ministry of Health and those made by the Paran & aacute; State Health Department. Methods: This was a retrospective observational study comparing prices of medications acquired centrally by the Brazilian Ministry of Health and those acquired by the State...


Empowering pharmacists working in primary care through a cardiovascular disease...

Moura, L; Chahal, J; Fernandez-Llimos, F; da Costa, FA; Antoniou, S

Introduction: Cardiovascular disease (CVD) is currently the leading cause of mortality and morbidity worldwide. A competent healthcare workforce working in primary care delivering disease management services efficiently is the cornerstone of well performing health systems, impacting patient outcomes positively. The aim of this study was to evaluate the effectiveness of a training course to support pharmacists w...


Impact of the COVID-19 pandemic on antidepressant consumption in the Central re...

Negrao, LG; Coelho, C; Castel-Branco, MM; Figueiredo, IV; Fernandez-Llimos, F

PurposeTo evaluate the impact of the pandemic on the consumption of antidepressive agents in Central Portugal.MethodsTo estimate the causal effect of the pandemic an interrupted time series analysis was conducted. Data of antidepressant drugs monthly dispensed in community pharmacies between Jan-2010 and Dec-2021 were provided by the regional Health Administration. Anti-Parkinson dopaminergic agents and statins...


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