2 documents found, page 1 of 1
Maturity-Onset Diabetes of the Young (MODY) in Portugal: Novel GCK, HNFA1 and H...
Alvelos, Maria I.; Gonçalves, Catarina I.; Coutinho, Eduarda; Almeida, Joana T.; Bastos, Margarida; Sampaio, Maria L.; Melo, Miguel; Martins, SofiaMaturity-onset diabetes of the young (MODY) is a frequently misdiagnosed type of diabetes, which is characterized by early onset, autosomal dominant inheritance, and absence of insulin dependence. The most frequent subtypes are due to mutations of the GCK (MODY 2), HNF1A (MODY 3), and HNF4A (MODY 1) genes. We undertook the first multicenter genetic study of MODY in the Portuguese population. The GCK, HNF1A, and...
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effec...
Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.; Peixoto, Daniela; Abreu, Rui M. V.; Silva, L. A. Vale; Pinto, Eugénia; Lima, Raquel T.Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The aminodi(hetero)arylamines thus obtained were evaluated for their growth inhibitory effect on four human tumor cell ...