16 documents found, page 1 of 2

Antinociceptive and anti-inflammatory activities of the lectin from Marine Red ...

Laboratório de Farmacologia de Venenos, Toxinas e Lectinas

O Laboratório de Farmacologia de Venenos, Toxinas e Lectinas, conhecido como LAFAVET, é um grupo de pesquisa que vem se dedicando a estudos de alterações renais causados por animais peçonhentos brasileiros, seus modos de ação e possíveis tratamentos. Atuante desde o ano de 1993 e coordenado pela Professora Doutora Helena Serra Azul Monteiro é certificado pela Universidade Federal do Ceará e CNPq. A grande impor...

Phosphodiesterase-5 inhibitor sildenafil attenuates kidney injury induced by Bo...

Made available in DSpace on 2022-04-29T08:33:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-30; Acute kidney injury pathogenesis in envenoming by snakes is multifactorial and involves immunologic reactions, hemodynamic disturbances, and direct nephrotoxicity. Sildenafil (SFC), a phosphodiesterase 5 inhibitor, has been reported to protect against pathological kidney changes. Objective: This study a...

K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom

Made available in DSpace on 2022-04-28T21:24:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01; The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect durin...

Veneno de Bothrops erythromelas ( Amaral, 1923 ) induz apoptose em células epit...

Bothrops erythromelas is responsible for a large number of snakebite incidents in Northeastern Brazil. Previously, we showed the effects of whole B. erythromelas venom in an isolated kidney model. To continue the study with B. erythromelas venom, the present work aims to study the effects of this venom on MDCK tubular epithelial cells and assess gene expression involved in kidney injury, aiming at elucidating t...

Bothrops pauloensis snake venom-derived Asp-49 and Lys-49 phospholipases A2 med...

Made available in DSpace on 2021-06-25T11:09:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-30; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); University of Cambridge; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The envenomation caused by the Bothrops pauloensis snake leads to severe loca...

Alterações histológicas e transporte de eletrólitos após administração de contr...

Objetivos: avaliar possíveis alterações renais causadas pelo contraste ioxitalamato de meglumina. Métodos: o contraste ioxitalamato de meglumina na dose de 5 mL/Kg (n=8) ou solução salina 0,9% na dose de 5 mL/Kg (n=5) foram administrados por via intravenosa em ratos Wistar machos (250-350g). Os animais foram mantidos em gaiolas metabólicas, e após 72 horas a função renal foi avaliada através de proteinúria, osm...

Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothel...

Made available in DSpace on 2018-12-11T17:14:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01; Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular e...

Alterações morfológicas de pele de camundongos inoculados com o veneno total da...

Snake venoms are composed of complex active substances, most of them of protein nature, causing various effects on humans and domestic animals and can lead to death. Philodryas nattereri is a native snake Ceara region, found throughout the state. This study aimed to know the morphological and physiological changes in mouse skin after inoculation with the total venom this serpente. The animals were divided into ...

In vitro evaluation of anti-Leishmania and anti-Trypanosoma cruzi activity of v...

The chemotherapy available for the treatment of Leishmaniosis and Chagas is restricted to a few medicines. Moreover, snake venoms have been studied because they have active substances with therapeutic potential. Thus, the aim of this study was to evaluate the in vitro effects of total venom of Crotalusdurissuscascavella , Crotalusdurissusterrificus and Bothropsjararaca in Leishmania chagasi and Trypanosoma cruz...