9 documents found, page 1 of 1
High efficacy of chloroquine-derived bile salts in Pluronic F127 micelles again...
Silva, Ana Teresa; Oliveira, Isabel S.; Morais, Inês; Santana, Sofia; Workneh, Eyob A.; Prudêncio, Miguel; Nogueira, Fátima; Ferraz, RicardoFunding Information: The authors thank Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia/Minist\u00E9rio da Educa\u00E7\u00E3o e Ci\u00EAncia \u2013 FCT/MEC, for PT national funds through the project CIRCNA/BRB/0281/2019. FCT/MCE is further acknowledged for supporting the Research Units LAQV-REQUIMTE (LA/P/0008/2020, UIDP/50006/2020 and UIDB/50006/2020), CIQUP (UIDB/00081/2020), IMS (LA/P/0056/2020), and GHTM...
Corrigendum to
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana M.; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise Maria Figueiredo Araújo; Nogueira, FátimaScheme 1 and Figure 1 in this article were incorrect. The correct ones, and their respective captions, follow: 1 Scheme (Figure presented.) Synthesis route to PQ-derived organic salts 3a–g. (i) 1a (1 molar equivalent, eq), 2a–g (1 eq), methanol (MeOH), room temperature (RT), 30 min. 1 Figure (Figure presented.) Surface tension plots and cmc determination, at 25 °C, of aqueous CTAB/SAIL mixtures: A) surface tens...
Drug-Derived Surface-Active Ionic Liquids
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise; Nogueira, Fátima; Prudêncio, MiguelFunding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH; In...
Synthesis and Biological Evaluation of Amphotericin B Formulations Based on Org...
Ferraz, Ricardo; Santarém, Nuno; Santos, Andreia F. M.; Jacinto, Manuel L.; Cordeiro-da-Silva, Anabela; Prudêncio, Cristina; Noronha, João PauloFunding text This research was funded by the project NORTE-01-0145-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work was also supported by the Associate Laboratory for Green Chemistry LAQV financed by national funds from FCT/MCTES (UIDB/50006/2020, UIDP/50006/2020 ...
Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma ...
Dias, Ana Rita; Ferraz, Ricardo; Costa-Rodrigues, João; Santos, Andreia F. M.; Jacinto, Manuel L.; Prudêncio, Cristina; Noronha, João PauloThe search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The to...
Tailoring amphotericin B as an ionic liquid
Hartmann, Diego O.; Shimizu, Karina; Rothkegel, Maika; Petkovic, Marija; Ferraz, Ricardo; Petrovski, Željko; Branco, Luís C.; Canongia Lopes, José N.Funding Information: This work was nancially supported by Fundação para a Ciência e a Tecnologia (FCT) by Project MOSTMICRO ITQB with refs UIDB/04612/2020 and UIDP/04612/2020, and by the European Research Council through grant ERC 2014-CoG-647928. The authors thank FCT for funding the Research Unit Centro de Qúımica Estrutural (UIDB/00100/2020 and UIDP/00100/2020) and project PTDC/QUI-QFI/29527/2017, and PT202...
Building on surface-active ionic liquids for the rescuing of the antimalarial d...
Silva, Ana Teresa; Lobo, Lis; Oliveira, Isabel S.; Gomes, Joana; Teixeira, Cátia; Nogueira, Fátima; Marques, Eduardo F.; Ferraz, Ricardo; Gomes, PaulaIonic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50...
Synthesis and antibacterial activity of ionic liquids and organic salts based o...
Ferraz, Ricardo; Silva, Dário; Dias, Ana Rita; Dias, Vitorino; Santos, Miguel M.; Pinheiro, Luís; Prudêncio, Cristina; Noronha, João PauloFundacao para a Ciencia e Tecnologia through projects (PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013) and PTDC/BTM-SAL/29786/2017, and one contract under Investigador FCT (L.C.B.). ZP thanks to Fundacao para a Ciencia e a Tecnologia, MCTES, for the Norma transitoria DL 57/2016 Program Contract. This work was also supported by the Associate Laboratory for Green Chemistry, which is financed by national funds from F...
Antitumor Activity of Ionic Liquids Based on Ampicillin
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria H.; Santos, Miguel; Marrucho, I. M.; Rebelo, Luis P. N.; Prudêncio, CristinaSignificant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic ampicillin with appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient ionic liquids (API-ILs) that show potent antiproliferative activities against five different human cancer cell lines: T47D (brea...