2 documents found, page 1 of 1
Nanostructured lipid carriers loaded with cannabidiol: A novel antibiofilm appr...
Cunha, Joana; Barreira, Sérgio; Ferraz, Maria; Catita, José; Lúcio, Marlene; Carla LopesIntroduction: Staphylococcus aureus and Staphylococcus epidermidis are major contributors to skin dysbiosis and infections, e.g. folliculitis and intravascular catheter infections, forming biofilms that enhance their resistance to antibiotics and immune responses. Given that antibiotic resistance is a serious challenge, new solutions are constantly being explored. The endocannabinoid system is essential for mai...
Tissue and cell-type dependent impact of secondary glucocerebrosidase abnormali...
Gaspar, Paulo; Kallemeijn, Wouter; Strijland, Anneke; Van Eijk, Marco; Van Roomen, Cindy; Ottenhoff, Roloef; Mirzaian, Mina; Ferraz, MariaSphingolipidoses comprise the most prevalent group of lysosomal storage disorders. The most frequent is Gaucher disease (GD), where it occurs the storage of the glycosphingolipid glucosylceramide (GlcCer) due to a deficiency in the enzyme glucocerebrosidase (GCase). GD is a multi-systemic disorder affecting most organs, resulting in cytopenia, hepatosplenomegaly and skeletal abnormalities. Only recently, lysoso...