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Prevention and treatment of oral adverse effects of antiresorptive medications ...
Madeira,Miguel; Rocha,André Caroli; Moreira,Carolina Aguiar; Aguiar,Águida Maria Menezes; Maeda,Sergio Setsuo; Cardoso,Abel SilveiraABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The...
Diagnosis and treatment of hypoparathyroidism: a position statement from the Br...
Maeda,Sergio Setsuo; Moreira,Carolina Aguiar; Borba,Victória Zeghbi Cochenski; Bandeira,Francisco; Farias,Maria Lucia Fleiuss deABSTRACT Objective To present an update on the diagnosis and treatment of hypoparathyroidism based on the most recent scientific evidence. Materials and methods The Department of Bone and Mineral Metabolism of the Sociedade Brasileira de Endocrinologia e Metabologia (SBEM; Brazilian Society of Endocrinology and Metabolism) was invited to prepare a document following the rules set by the Guidelines Program of th...
Genetics of osteoporosis: searching for candidate genes for bone fragility
Rocha-Braz,Manuela G. M.; Ferraz-de-Souza,BrunoABSTRACT The pathogenesis of osteoporosis, a common disease with great morbidity and mortality, comprises environmental and genetic factors. As with other complex disorders, the genetic basis of osteoporosis has been difficult to identify. Nevertheless, several approaches have been undertaken in the past decades in order to identify candidate genes for bone fragility, including the study of rare monogenic syndr...