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Matrix metalloproteinases in focus: an exploratory epidemiological study in a N...
Foresti, Manon; Garcia, Catarina; Gonçalves, Maria; Relvas, Marta; Viana da Costa, AlexandraBackground: Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that regulate extracellular matrix degradation and remodelling. Among them, MMP-8 and MMP-9 are key mediators of inflammation, tissue remodelling, and wound healing. They have been implicated in both type 1 diabetes mellitus (T1DM) and periodontal disease (PD) [1]. The literature indicates a bidirectional association between T1DM and PD: ch...
In the network of periodontitis immunomediators
Viana da Costa, Alexandra; Mendes-Frias, Ana; Gonçalves, Maria; Salazar, Filomena; Silvestre, Ricardo; Relvas, MartaBackground: Severe periodontitis is considered the sixth most prevalent disease worldwide [1]. It is a chronic inflammatory condition affecting the tooth-supporting structures due to genetic, environmental, and microbial factors [2]. The host immune response partially contributes to the magnitude of the inflammatory process. Furthermore, this process involves a diversity of immunomediators that initiate and sus...
Analysis of salivary levels of IL-1β, IL17A, OPG and RANK-L in periodontitis us...
Relvas, Marta; Silvestre, Ricardo Jorge Leal; Gonçalves, Maria; Cabral, Cristina; Frias, Ana Isabel Mendes; Monteiro, Luís; Viana da Costa, AlexandraPeriodontitis is a chronic disease with a high overall prevalence. It involves a complex interplay between the immune-inflammatory pathways and biofilm changes, leading to periodontal attachment loss. The aims of this study were (i) to assess whether the salivary IL-1β, IL-17A, RANK-L and OPG levels have the potential to discriminate between the mild and severe periodontitis conditions; and (ii) to enable diagn...