33 documents found, page 1 of 4
Integration of FTIR spectroscopy and machine learning for kidney allograft reje...
Ramalhete, Luís; Araújo, Rúben Alexandre Dinis; Bigotte Vieira, Miguel; Vigia, Emanuel; Aires, Inês; Ferreira, Aníbal; Calado, CecíliaKidney transplantation is a life-saving treatment for end-stage kidney disease, but allograft rejection remains a critical challenge, requiring accurate and timely diagnosis. The study aims to evaluate the integration of Fourier Transform Infrared (FTIR) spectroscopy and machine learning algorithms as a minimally invasive method to detect kidney allograft rejection and differentiate between T Cell-Mediated Reje...
Integrated Care for Kidney Disease in Portugal: Barriers to Access to Therapeut...
Aranda da Silva, José; Ferreira, Aníbal; Costa, Eduardo; Rodrigues, Anabela; Almeida, Edgar; Calixto, Liliana; Dinis, Paulo; Henriques, AntónioA Reunião de Reflexão, realizada a 4 de julho de 2025, teve como principal objetivo a análise crítica do atual modelo de prestação de cuidados a doentes com doença renal crónica (DRC) em Portugal, com especial enfoque no acesso à inovação terapêutica e equidade na prestação de cuidados. Pretendeu-se reunir um conjunto alargado de perspetivas técnicas e clínicas que pudessem contribuir para a identificação de po...
Calcium Polystyrene Sulfonate-Induced Colitis: Advanced Characterization of Cry...
Vidal, Helena; Salgado, Vilma; Alves, Patrícia; Fonseca, Nuno Moreira; Frochot, Vincent; Ferreira, AníbalClassical potassium binders are used in the treatment of hyperkalemia and are widely associated with gastrointestinal side effects, with crystal colonic injury being rare but potentially fatal. In this report, we describe the case of an 82-year-old male with hyperkalemia and calcium polystyrene sulfonate crystal-associated colonic necrosis. Traditionally, this diagnosis has relied on the examination of crystal ...
Exosomes and microvesicles in kidney transplantation: the long road from trash ...
Ramalhete, Luís; Araújo, Rúben; Ferreira, Aníbal; Calado, CecíliaKidney transplantation significantly enhances the survival rate and quality of life of patients with end-stage kidney disease. The ability to predict post-transplantation rejection events in their early phases can reduce subsequent allograft loss. Therefore, it is critical to identify biomarkers of rejection processes that can be acquired on routine analysis of samples collected by non-invasive or minimally inv...
Risk Factors of Acute T‐Cell Mediated and Borderline Rejection Diagnosed in Ear...
Roldão, Marisa; Vida, Ana Carlota; Monteiro Dias, Joana; Bigotte Vieira, Miguel; Magriço, Rita; Silva, Cecília; Caeiro, Fernando; Aires, InêsIntroduction: Acute graft rejection remains one of the main causes of graft dysfunction and premature loss. Under‐ standing the factors affecting graft rejection is essential to promote graft survival. Our study aimed to determine the incidence and assess risk factors of acute T‐cell mediated rejection (TCMR) and borderline rejection in early protocol kidney transplant biopsies. Methods: Retrospective single‐ce...
Predicting cellular rejection of renal allograft based on the serum proteomic f...
Ramalhete, Luís; Vieira, Miguel Bigotte; Araújo, Rúben; Vigia, Emanuel; Aires, Inês; Ferreira, Aníbal; Calado, CecíliaKidney transplantation is an essential medical procedure that significantly enhances the survival rates and quality of life for patients with end-stage kidney disease. However, despite advancements in immunosuppressive therapies, allograft rejection remains a leading cause of organ loss. Notably, predictions of cellular rejection processes primarily rely on biopsy analysis, which is not routinely performed due ...
Hyperkalemia management: a multidisciplinary expert panel’s perspective on the ...
Fonseca, Cândida; Garagarza, Cristina; Silva, Gil; Caires, Graça; Marques, Irene; Lopes, José António; Branco, Patrícia; Alves, Rui; Ferreira, AníbalHyperkalemia is a potentially life-threatening condition frequently encountered in clinical practice, particularly among patients with chronic kidney disease, heart failure, diabetes, and hypertension and those undergoing treatment with renin-angiotensin-aldosterone system inhibitors (RAASi). The management of chronic and acute hyperkalemia is complex and requires timely intervention to prevent severe complicat...
Label-free discrimination of T and B lymphocyte activation based on vibrational...
Ramalhete, Luís; Araújo, Rúben; Ferreira, Aníbal; Calado, CecíliaB and T-lymphocytes are major players of the specific immune system, responsible by an efficient response to target antigens. Despite the high relevance of these cells’ activation in diverse human pathophysiological pro cesses, its analysis in clinical context presents diverse constraints. In the present work, MIR spectroscopy was used to acquire the cells molecular profile in a label-free, simple, rapid, econo...
Label-free discrimination of T and B lymphocyte activation based on vibrational...
Ramalhete, Luís; Araújo, Rúben; Ferreira, Aníbal; Calado, CecíliaB and T-lymphocytes are major players of the specific immune system, responsible by an efficient response to target antigens. Despite the high relevance of these cells’ activation in diverse human pathophysiological processes, its analysis in clinical context presents diverse constraints. In the present work, MIR spectroscopy was used to acquire the cells molecular profile in a label-free, simple, rapid, econom...
Discriminative segmental cues to vowel height and consonantal place and voicing...
Jesus, Luís M. T.; Castilho, Sara; Ferreira, Aníbal; Costa, Maria ConceiçãoPurpose The acoustic signal attributes of whispered speech potentially carry sufficiently distinct information to define vowel spaces and to disambiguate consonant place and voicing, but what these attributes are and the underlying production mechanisms are not fully known. The purpose of this study was to define segmental cues to place and voicing of vowels and sibilant fricatives and to develop an articulator...