18 documents found, page 1 of 2

The influence of organizational readiness on knowledge translation and implemen...

Healthcare institutions face daily challenges that require professionals to adapt their clinical practice to the best available scientific evidence (Teixeira et al., 2022). This need to bridge the gap between professional practice and scientific evidence becomes even more relevant when considering the growing commitment of healthcareprofessionals to align their interventions with the most recent scientific adva...

Intervenções de enfermagem implementadas no serviço de urgência à pessoa vítima...

Introdução: O Acidente Vascular Cerebral (AVC) é uma emergência médica com impacto negativo na vida das pessoas. As intervenções administradas no Serviço de Urgência além de serem determinantes para minimizar as complicações tardias decorrentes do AVC, favorecem a qualidade dos cuidados prestados à pessoa na fase mais aguda do quadro clínico. Objetivo: Mapear as intervenções de enfermagem implementadas ao adult...

Effectiveness of educational videos on patient’s preparation for diagnostic pro...

Although diagnostic procedures are crucial for secondary prevention and patient disease control, they often trigger fear and anxiety. These reactions highlight the need to adopt effective interventions to improve patients' experience and satisfaction. Recently, educational videos have been employed in preparing diagnostic procedures; however, there is no integrated understanding of their effects. This systemati...

Voluntary running rescues the defective hippocampal neurogenesis and behaviour ...

The continuous generation of new neurons in the adult mammalian hippocampus is a form of neural plasticity that modulates learning and memory functions, and also emotion (anxiety and depression). Among the factors known to modulate adult hippocampal neurogenesis and brain function, lipocalin-2 (LCN2) was recently described as a key regulator of neural stem cells (NSCs) proliferation and commitment, with impact ...

Levantamento e análise de dados de subprodutos provenientes de actividade hortí...

Adult Hippocampal Neurogenesis Modulation by the Membrane-Associated Progestero...

Neudesin (Neuron-derived neurotrophic factor, NENF), a membrane-associated progesterone receptor family (MAPR) member, is a neuron secreted protein with neurotrophic properties during embryonic stages. However, its role in the adult brain is still poorly addressed. In this study we have used neudesin-null (Nenf-/-) mice and performed a characterization of the proliferation state of the adult neurogenic niches, ...

Metabolism and adult neurogenesis: Towards an understanding of the role of lipo...

The process of generating new functional neurons in the adult mammalian brain occurs from the local neural stem and progenitor cells and requires tight control of the progenitor cell's activity. Several signaling pathways and intrinsic/extrinsic factors have been well studied over the last years, but recent attention has been given to the critical role of cellular metabolism in determining the functional proper...

Insights on the pathophysiology of Alzheimer's disease: the crosstalk between a...

Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is growing along with the increased life expectancy. Although the accumulation and deposition of amyloid beta (Aß) peptides in the brain is viewed as one of the pathological hallmarks of AD and underlies, at least in part, brain cell dysfunction and behavior alterations, the etiology of this neurodegenerative disease is still poorly ...

Architectural Summer School: Projectar em tempos de escassez

Assiste-se, nos últimos anos, a uma transformação das práticas profissionais do arquitecto: a par do modelo tradicional – ciclo desenvolvido em atelier, da encomenda do projeto à construção do edifício –, novas práticas de intervenção do arquitecto, que designaremos aqui, num primeiro momento, como “práticas emergentes”. Como resultado desta transformação, surgem interrogações, nomeadamente no interior do própr...

The positive effect on ketamine as a priming adjuvant in antidepressant treatment.

Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal mod...