Administering propofol intravenously adequately during induction of general anesthesia implies a good knowledge of pharmacokinetics and pharmacodynamics, a good understanding of how anesthesia alters consciousness and the ability to correctly interpret vital signs monitoring. The purpose of this study was to assess the usual practice of anesthesiologists in Portugal regarding the administration of propofol duri...
Background: The amount of propofol needed to induce loss of responsiveness varied widely among patients, and they usually required less than the initial dose recommended by the drug package inserts. Identifying precisely the moment of loss of responsiveness will determine the amount of propofol each patient needs. Currently, methods to decide the exact moment of loss of responsiveness are based on subjective an...