A 63-year-old male, with type 2 diabetes, hypertension and atrial fibrillation, presented with complaints of typical angina. The electrocardiogram and transthoracic echocar diogram were unremarkable. He began antianginal drugs and was referred for an elective coronary angiography that showed multiple giant aneurysms on both coronary arteries (Figure 1, panels A and B). A computed tomography coronary angiography...
Introduction: Involuntary hospitalization of a patient with a mental disorder is broadly defined as the admission to an inpatient unit without the patient’s consent. Literature suggests that involuntary hospitalizations are associated with low levels of treatment satisfaction, avoidance of mental health care, and an increased risk of emergency involuntary re-hospitalization. Despite being a lifesaving treatment...
Purpose To understand court decisions in custody cases involving allegations of domestic violence, a qualitative study was conducted among Portuguese family court magistrates. Methods A nonprobabilistic snowball sampling process, which involved six judges from Portuguese family courts who were authorized by the Superior Magistrate’s Court to participate in an interview, was used to construct the sample. Results...
Influenza A virus (IAV) employs multiple strategies to manipulate cellular mechanisms and support proper virion formation and propagation. In this study, we performed a detailed analysis of the interplay between IAV and the host cells’ proteostasis throughout the entire infectious cycle. We reveal that IAV infection activates the inositol requiring enzyme 1 (IRE1) branch of the unfolded protein response, and th...
Background and Objectives: The optimal management of high-risk and intermediate-high-risk Pulmonary Embolism (PE) is a matter of ongoing debate. This paper aims to assess the short and long-term clinical outcomes associated with different treatment approaches for high-risk and intermediate-high-risk PE within an Intensive Care Unit (ICU) and identify potential areas for improvement. Methods: We conducted a retr...
Introdução: O perfil de competências foi produzido a partir do Conselho Internacional de Enfermeiros que representa a “voz” internacional da Enfermagem e que trabalhou para garantir cuidados de qualidade para todos e políticas de saúde adequadas a nível global. Neste sentido, em 2003 a Ordem dos Enfermeiros criou um documento para identificar as competências do enfermeiro generalista no início de carreira profi...
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The importance of peroxisomes in the context of viral infections has been increasingly demonstrated in recent years. The discovery that MAVS localizes at peroxisomes and that peroxisomal and mitochondrial MAVS perform complementing functions within the antiviral response has raised the interest in studying the peroxisome-dependent signaling in the context of infection by different viruses. To that end, specific...
Peroxisomes have recently been shown to play important roles in the context of viral infections. However, further and more detailed studies should be performed to unravel the specific mechanisms involved. The analysis of the relevance of particular peroxisomal components, such as peroxisomal proteins, for viral infections can be performed by comparing the production of new virus particles in the absence and pre...
The general interest in the study of the interplay between peroxisomes and viruses has increased in recent years, with different reports demonstrating that distinct viruses modulate peroxisome-related mechanisms to either counteract the cellular antiviral response or support viral propagation. Nevertheless, mechanistical details are still scarce, and information is often incomplete. In this chapter, we present ...