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Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...
Moura, Ágata Nogueira D’Áurea; Oliveira, Diane Sthefany Lima de; Paredes, Verenice; Rocha, Leticia Barboza; Oliveira, Fabiana Freire Mendes deParacoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...
Development and characterization of recombinant antibody Fragments that recogni...
Luz, Daniela; Chen, Gang; Maranhão, Andrea Queiroz; Rocha, Leticia Barboza; Sidhu, Sachdev; Piazza, Roxane Maria FontesBackground: Stx toxin is a member of the AB5 family of bacterial toxins: the active A subunit has N-glycosidase activity against 28S rRNA, resulting in inhibition of protein synthesis in eukaryotic cells, and the pentamer ligand B subunits (StxB) bind to globotria(tetra)osylceramide receptors (Gb3/Gb4) on the cell membrane. Shiga toxin-producing Escherichia coli strains (STEC) may produce Stx1 and/or Stx2 and v...