16 documents found, page 1 of 2
Association of statin use on survival outcomes of patients with early-stage HER...
Maurer, Christian; Agostinetto, Elisa; Ameye, Lieveke; Lambertini, Matteo; Martel, Samuel; Ponde, Noam; Brandão, Mariana; Poggio, FrancescaPurpose There is evidence that statins might improve the outcome of patients with breast cancer. The role of statins in patients with early HER2-positive breast cancer is unknown. Therefore, we explored the association between statin use and survival outcomes in early HER2-positive breast cancer patients in the phase III APHINITY trial (adjuvant pertuzumab/ trastuzumab). Methods All patients (intent-to-treat po...
Association between pertuzumab-associated diarrhoea and rash and survival outco...
Ferreira, Arlindo; Ferreira, Sofia; Lambertini, Matteo; Maurer, Christian; Martel, Samuel; Costa, Luis; Ponde, Noam; Azambuja, Evandro deBackground: Skin rash and diarrhoea are known side-effects of pertuzumab. Studies with other anti-HER2 agents suggested that adverse events correlate with patient outcomes. In this exploratory cohort of patients with metastatic HER2-positive breast cancer included in the CLEOPATRA trial we evaluated the value of rash and diarrhoea as prognostic markers and as predictors of pertuzumab benefit. Methods: This is a...
Breast cancer surgery with augmented reality
Gouveia, Pedro; Costa, Joana; Morgado, Pedro; Kates, Ronald; Pinto, David; Mavioso, Carlos; Anacleto, João; Martinho, Marta; Lopes, Daniel SimõesIntroduction: Innovations in 3D spatial technology and augmented reality imaging driven by digital high-tech industrial science have accelerated experimental advances in breast cancer imaging and the development of medical procedures aimed to reduce invasiveness. Presentation of case: A 57-year-old post-menopausal woman presented with screen-detected left-sided breast cancer. After undergoing all staging and pr...
Adjuvant endocrine therapy for the treatment of early breast cancer : real worl...
Ferreira, ArlindoO tratamento hormonal adjuvante de doentes com carcinoma da mama melhora a sobrevivência global. O uso em contexto de mundo real, efetividade, tolerabilidade e adesão a inovações recentes da terapia hormonal adjuvante de cancro da mama não está bem caracterizado. Para abordar estes pontos e assim apoiar a tomada de decisão de doentes-médicos e a investigação clínica futura desenvolvemos uma série de projetos co...
Impact of extraskeletal metastases on skeletal-related events in metastatic cas...
Lobo-Martins, Soraia; Ferreira, Arlindo; Mansinho, André; Casimiro, Sandra; Leitzel, Kim; Ali, Suhail; Lipton, Allan; Costa, LuisThe therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC) has substantially evolved over the last decade. Nonetheless, a better understanding of bone-targeted agents (BTAs) action in mCRPC remains an unmet need. Theuse of BTAs aims to reduce the incidence of skeletal-related events (SREs) in patients with mCRPC. Less frequent BTA schedules are currently being studied to minimize adver...
Mixed invasive ductal and lobular carcinoma of the breast: prognosis and the im...
Metzger-Filho, Otto; Ferreira, Arlindo; Jeselsohn, Rinath; Barry, William T.; Dillon, Deborah A.; Brock, Jane E.; Vaz-Luis, Ines; Hughes, Melissa E.Background: The diagnosis of mixed invasive ductal and lobular carcinoma (IDC-L) in clinical practice is often associated with uncertainty related to its prognosis and response to systemic therapies. With the increasing recognition of invasive lobular carcinoma (ILC) as a distinct disease subtype, questions surrounding IDC-L become even more relevant. In this study, we took advantage of a detailed clinical data...
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in canc...
Mansinho, André; Ferreira, Arlindo; Casimiro, Sandra; Alho, Irina; Vendrell, Ines; Costa, Ana Lúcia; Sousa, Rita; Marques, Catarina; Pulido, CatarinaThe fibroblast growth factor (FGF) signaling pathway plays a key role in tumorigenesis and is recognized as a potential therapeutic target. In this study, the authors aimed to assess the impact of serum FGF23 levels in the prognosis of patients with cancer and bone metastases from solid tumors. A cohort of 112 patients with cancer and metastatic bone disease were treated with bone-targeted agents (BTA). Serum b...
Endocrine therapy and palbociclib within a compassionate use program in heavily...
Maurer, Christian; Ferreira, Arlindo; Martel, Samuel; Lambertini, Matteo; Pondé, Noam; Aftimos, Philippe; de Azambuja, Evandro; Piccart, MartineThis is a single center retrospective analysis of patients with hormone receptor-positive, HER2-negative metastatic breast cancer progressing after ≥ 4 treatment lines treated with palbociclib in combination with endocrine therapy within a compassionate use program. Thirty-four patients were included between 10/2015 and 02/2017, the majority (82.4%) being previously treated with mTOR inhibitors. Disease control...
Chemoradiotherapy completion and neutropenia risk in HIV patients with cervical...
Vendrell, Ines; Ferreira, Arlindo; Abrunhosa-Branquinho, André; Semedo, Patrícia Miguel; Pulido, Catarina F.; Jorge, Marília; Pina, Maria FilomenaCervical cancer (CC) is one of the acquired immunodeficiency syndrome (AIDS) defining diseases and the human immunodeficiency virus (HIV) infection is thought to relate with increased acute toxicity of chemoradiotherapy (CRT). We investigated the effect of HIV status in the incidence of neutropenia associated with cisplatin-based CRT for CC and its impact in treatment completion. This is a single-center retrosp...
Bone metastasis risk factors in breast cancer
Pulido, Catarina; Vendrell, Ines; Ferreira, Arlindo; Casimiro, Sandra; Mansinho, André; Alho, Irina; Costa, LuisBone is the single most frequent site for bone metastasis in breast cancer patients. Patients with bone-only metastasis have a fairly good prognosis when compared with patients with visceral disease. Nevertheless, cancer-induced bone disease carries an important risk of developing skeletal related events that impact quality of life (QoL). It is therefore particularly important to stratify patients according to ...