7 documents found, page 1 of 1
Regulation of pulmonary CD4+ T cell responses to Mycobacterium tuberculosis inf...
Ferreira, Catarina MachadoA pandemia de COVID-19 reverteu os sucessos de anos anteriores no que diz respeito ao fornecimento de serviços essenciais de combate à tuberculose e ao decréscimo da sua incidência. Pela primeira vez em mais de uma década, a mortalidade da tuberculose aumentou, e estima-se que atingirá as 1,4 milhões de mortes até 2025. Portanto, são urgentes avanços científicos que contribuam para mitigar estes efeitos. O cont...
The impact of IL-10 dynamic modulation on host immune response against visceral...
Mesquita, Inês Morais; Ferreira, Carolina; Barbosa, Ana Margarida; Ferreira, Catarina Machado; Moreira, Diana; Carvalho, Agostinho; Cunha, CristinaLeishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sul...
Immune-evasion strategies of mycobacteria and their implications for the protec...
Fraga, Alexandra G.; Barbosa, Ana Margarida Martins; Ferreira, Catarina Machado; Fevereiro, João; Pedrosa, Jorge; Torrado, EgídioMycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection...
A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tubercu...
Bhatt, Kiranmai; Machado, Henrique Pedro Pereira Silva Amaral; Osório, Nuno S.; Sousa, Jeremy; Cardoso, Filipa; Magalhães, Carlos André RodriguesNonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...
Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in...
Miranda, Margarida Silva; Rodrigues, Márcia T.; Domingues, Rui Miguel Andrade; Costa, Rui R.; Paz, Elvira; Rodríguez-Abreu, Carlos; Freitas, PauloTuberculosis (TB) is an infectious disease which affects millions of people worldwide. Inhalable polymeric dry powders are promising alternatives as anti-TB drug carriers to the alveoli milieu and infected macrophages, with potential to significantly improve the therapeutics efficiency. Here, the development of a magnetically responsive microparticulate system for pulmonary delivery of an anti-TB drug candidate...
Characterizing the initial cellular and molecular events of the protective immu...
Ferreira, Catarina MachadoTuberculosis (TB) is an aerosol-transmitted disease caused by Mycobacterium tuberculosis. Infections by M. tuberculosis are initiated with the deposition of the bacteria in the lower airways, where alveolar macrophages are thought to be the first cells to recognize and engulf the bacteria. Nonetheless, it is only after the onset of the acquired immune response, mediated by IFN-ɀ-producing CD4+ T cells, that bac...
Relatório estágio profissional
Ferreira, Catarina MachadoRelatório final do estágio profissionalizante do 6.º ano