50 documents found, page 1 of 5
World Heart Federation Cholesterol Roadmap: The Portuguese case
Abreu, A; Dores, H; Gonçalves, L; Franco, F; Silveira, C; Proença, G; Teresa Timóteo, A; Cardim, N; Pedro, M; Fiuza, M; Ferreira, D; Bento, LAtherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability; effective cardiovascular (CV) risk prevention is fundamental. The World Heart Federation (WHF) Cholesterol Roadmap provides a framework for national policy development and aims to achieve ASCVD prevention. At the invitation of the WHF, a group of experts from the Portuguese Society of Cardiology (SPC), addr...
Complex Long-Term Catatonia
Rema, JP; Cavaco, T; Ferreira, D; Pereira, JM
A Step Forward in Breast Cancer Research: a Preliminary Photothermal Approach U...
Ferreira-Gonçalves, T; Costa, E; Coelho, JMP; Gaspar, MM; Ascenção, L; Faísca, P; Figueiredo, VF; Ferreira, D; Ferreira, H; Reis, CPBreast cancer is a leading cause of cancer deaths among women worldwide and comprehends a group of heterogeneous tumors with variable prognosis. A strong investment was made over time and several therapeutic options were proposed. Conventional treatments are still based on surgery and chemo- and radiation therapy, which are generally associated with high invasiveness, extensive side effects and low specificity....
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker trigger...
Peixoto, A; Ferreira, D; Azevedo, R; Freitas, R; Fernandes, E; Relvas-Santos, M; Gaiteiro, C; Soares, J; Cotton, S; Teixeira, B; Paulo, P; Lima, LBackground: Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia and nutrient deprivation, oversialylation and O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential. Meth...
Patients' perspective and lung function correlation:the importance of questionn...
Fonseca, AD; Marques, MS; Conde, S; Oliveira, P; Nogueira, C; Ferreira, D; Adler, D; Windisch, W; Nunes, R; Ribeiro, CClassical physiological variables used to monitor respiratory function in patients under non-invasive ventilation (NIV), such as FEV1 or FVC, correlate poorly with reported impairment of physical function or overall health status and hence provide an incomplete picture of impaired health. Aim: to investigate the association between the Portuguese S3-non-invasive ventilation (S3-NIV) questionnaire score and obje...
Target score—a proteomics data selection tool applied to esophageal cancer iden...
Cotton, S; Ferreira, D; Soares, J; Peixoto, A; Relvas-Santos, M; Azevedo, R; Piairo, P; Diéguez, L; Palmeira, C; Lima, L; Silva, AMN; Santos, LLEsophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a g...
The Portuguese S3-Non-invasive Ventilation (S3-NIV) questionnaire for home mech...
Ribeiro, C; Conde, S; Oliveira, P; Nogueira, C; Ferreira, D; Adler, D; Windisch, W; Nunes, RShort, valid and easy to use tools are needed to monitor home mechanical ventilation (HMV) in clinical practice and for organization of HMV services. The S3NIV is a self-administered questionnaire containing 11 items that includes a Respiratory Symptoms and Sleep & Side Effects subscores, ranging from 0 (highest impact of disease and treatment) to 10 (lowest impact of disease and treatment). The Portuguese vers...
A Fast Alternative to Soft Lithography for the Fabrication of Organ-on-a-Chip E...
Ferreira, D; Rothbauer, M; Conde, JP; Ertl, P; Oliveira, C; Granja, PLOrgan-on-a-chip technology promises to revolutionize how pre-clinical human trials are conducted. Engineering an in vitro environment that mimics the functionality and architecture of human physiology is essential toward building better platforms for drug development and personalized medicine. However, the complex nature of these devices requires specialized, time consuming, and expensive fabrication methodolog...
Anaphylaxis in an emergency department: a retrospective 10-year study in a tert...
Alen Coutinho, I.; Ferreira, D; Regateiro, FS; Pita, J; Ferreira, M; Martins, JF; Fonseca, IA; Loureiro, C; Todo-Bom, ABackground. Anaphylaxis is a potentially fatal medical emergency. The frequency of hospital admissions for anaphylaxis seems to be increasing in the recent decades. Objective. Characterize the patients admitted for anaphylaxis to the adult emergency department (ED) of a tertiary care hospital over a 10-year period, discriminating aetiologies, clinical features and therapy administered. Methods. Retrospective, d...
Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microf...
Carvalho, S; Abreu, CM; Ferreira, D; Lima, L; Ferreira, JA; Santos, LL; Ribeiro, R; Grenha, V; Martínez-Fernández, M; Duenas, M; Suárez-Cabrera, CBladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrich...